appican

chondroitin sulfate (CS) proteoglycan form of the amyloid precursor protein, expressed in human & rat brain; may play a role in the development of Alzheimer's disease neuropathology

Also Known As:

Networked: 5 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Nishimura, Shuji: 1 article (01/2004)
2.	Robakis, Nikolaos K: 1 article (01/2004)
3.	Shioi, Junichi: 1 article (01/2004)
4.	Sugahara, Kazuyuki: 1 article (01/2004)
5.	Umehara, Yuko: 1 article (01/2004)
6.	Yamada, Shuhei: 1 article (01/2004)

Related Diseases

1.	Glioma (Gliomas) 07/01/1997 - "Here, we report that rat C6 glioma cells transfected with appican displayed a dramatic change in their phenotypic appearance compared with untransfected cells or cells transfected with APP. " 07/01/1997 - "Appican expression induces morphological changes in C6 glioma cells and promotes adhesion of neural cells to the extracellular matrix." 12/01/1996 - "Transfected C6 glioma cells overexpressing appican remained attached to tissue culture dishes markedly better than either C6 cells over-expressing exon-15 containing APP or WT C6 cells. " 05/05/1995 - "Transfection of C6 glioma or 293 kidney fibroblast cells with APP cDNAs containing exon 15 produced no appican, while transfection with an APP cDNA lacking this exon induced high levels of appican production. " 01/16/2004 - "In this study, the appican CS chain from rat C6 glioma cells was shown to specifically bind several growth/differentiation factors including midkine (MK) and pleiotrophin (PTN). "
2.	Neuroblastoma 12/01/1996 - "Appican-enriched extracellular matrix (ECM) was also observed to serve as a much better substrate for attachment of N2a neuroblastomas, pheocromocytoma PC12 cells and primary astrocytes compared to APP enriched ECM." 12/01/1996 - "Appican is expressed by certain transformed cell lines of neural origin, namely C6 cells and N2a neuroblastomas. " 05/19/1995 - "N2a neuroblastoma cells also produced appican; however, treatment with dibutyryl cAMP which promotes neuronal differentiation in these cells inhibited its production without inhibiting synthesis of APP. " 07/01/1997 - "ECM from appican-transfected C6 cultures stimulated adhesion of other neural cells including primary astrocytes, Neuro2a neuroblastoma, and PC12 pheochromocytoma, but not fibroblast cells. " 01/16/2004 - "In contrast, the appican CS from SH-SY5Y neuroblastoma cells contained no E disaccharide and showed no binding to either MK or PTN. "
3.	Pheochromocytoma 07/01/1997 - "ECM from appican-transfected C6 cultures stimulated adhesion of other neural cells including primary astrocytes, Neuro2a neuroblastoma, and PC12 pheochromocytoma, but not fibroblast cells. "

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	Amyloid (Amyloid Fibrils)
3.	Growth Differentiation Factors
4.	Chondroitin Sulfate Proteoglycans
5.	Midkine
6.	pleiotrophin (HARP)
7.	Complementary DNA (cDNA)
8.	Proteoglycans (Proteoglycan)
9.	Heparin (Liquaemin)
10.	Disaccharides