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lamina-associated polypeptide 2

an integral membrane protein of the inner nuclear membrane; amino acid sequence given in first source; GenBank U18314

Also Known As:

LAP2 (protein); LAP2alpha; LAP2beta

Networked: 15 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Membrane Proteins: 10078
    - lamina-associated polypeptide 2: 15
  - DNA-Binding Proteins: 2009
    - lamina-associated polypeptide 2: 15

Experts

1.	Foisner, Roland: 5 articles (02/2010 - 12/2005)
2.	Stewart, Colin L: 3 articles (02/2010 - 06/2008)
3.	Vlcek, Sylvia: 3 articles (04/2006 - 03/2004)
4.	Gotic, Ivana: 2 articles (02/2010 - 11/2008)
5.	Cohen, Tatiana V: 2 articles (11/2008 - 06/2008)
6.	Dorner, Daniela: 2 articles (11/2008 - 04/2006)
7.	Korbei, Barbara: 2 articles (11/2008 - 06/2008)
8.	Gajewski, Andreas: 2 articles (04/2006 - 12/2005)
9.	Gotzmann, Josef: 2 articles (04/2006 - 12/2005)
10.	Chang, Jianhua: 1 article (01/2019)

Related Diseases

1.	Retinoblastoma (Glioblastoma, Retinal) 03/01/2004 - "LAP2alpha, retinoblastoma, E2F-DP heterodimers, genes) as 'food for thought'. " 04/10/2006 - "The LAP2alpha-linked cell cycle phenotype is mediated by the retinoblastoma (Rb) protein because the LAP2alpha COOH terminus directly bound Rb, and overexpressed LAP2alpha inhibited E2F/Rb-dependent reporter gene activity in G1 phase in an Rb-dependent manner. "
2.	Neoplasms (Cancer) 06/01/2006 - "In agreement with its regulation by E2F, LAP2alpha over expression in primary tumors was found to be correlated with tumor proliferation rate." 06/01/2006 - "Lap2alpha expression is controlled by E2F and deregulated in various human tumors." 06/01/2006 - "We studied the expression level of LAP2alpha in human tumors by tissue microarray analysis and found LAP2alpha over expression in a significant percentage of primary larynx, lung, stomach, breast, and colon cancer tissues. " 01/16/2014 - "Phosphopeptides that belong to the proteins lamina-associated polypeptide 2 isoform alpha and serine-arginine repetitive matrix protein 2 were identified with differential abundance and they appear as promising tumor-related phosphopeptides. "
3.	Infections 06/01/2008 - "We observed HIV-1 and MLV infectivity in mouse embryonic fibroblasts (MEFs) from emerin knockout, LAP2alpha knockout, or emerin and LAP2alpha double knockout mice to be comparable in infectivity to wild-type littermate-derived MEFs, indicating that both emerin and LAP2alpha were dispensable for HIV-1 and MLV infection of dividing, primary mouse cells. " 06/01/2008 - "The LEM domain proteins emerin and LAP2alpha are dispensable for human immunodeficiency virus type 1 and murine leukemia virus infections." 01/01/2007 - "In contrast, we determined efficient HIV-1 and MMLV infection of HeLa-P4 cells following potent down-regulation of emerin, BAF, or LAP2alpha protein by using short interfering RNA. "
4.	Laminopathies 11/01/2008 - "Mutations in both LAP2alpha and A-type lamins are linked to human diseases called laminopathies, but the molecular mechanisms are poorly understood. " 04/01/2011 - "Lamin-binding proteins implicated in laminopathies include lamin B2, nuclear envelope proteins such as emerin, MAN1, LBR, and nesprins, the nuclear matrix protein matrin 3, the lamina-associated polypeptide, LAP2alpha and the transcriptional regulator FHL1. "
5.	Non-alcoholic Fatty Liver Disease 01/01/2018 - "Several variants in nuclear lamina-related genes were identified in a cohort of twins and siblings with NAFLD; one such variant, which results in a truncated LAP2 protein and a dramatic phenotype in cell culture, represents an association of TMPO/LAP2 variants with NAFLD and underscores the potential importance of the nuclear lamina in NAFLD. "

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	Lamins
3.	emerin
4.	Lamin Type B (Lamin B)
5.	Histones (Histone)
6.	MEF2 Transcription Factors
7.	Small Interfering RNA (siRNA)
8.	Nuclear Matrix-Associated Proteins
9.	Sirolimus (Rapamycin)
10.	Protein Isoforms (Isoforms)