nuclear pore complex protein 98

a nucleoporin of 98 kDa; functions as a docking site in transport across the nuclear pore complex; amino acid sequence given in first source; GenBank L39991

Also Known As:

NUP98; nucleoporin, Nup98

Networked: 236 relevant articles (4 outcomes, 16 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Carrier Proteins: 12999
    - Membrane Transport Proteins: 589
      - Nucleocytoplasmic Transport Proteins: 2
        Nuclear Pore Complex Proteins: 251
        nuclear pore complex protein 98: 236
  - Membrane Proteins: 10078
    - Membrane Transport Proteins: 589
      - Nucleocytoplasmic Transport Proteins: 2
        Nuclear Pore Complex Proteins: 251
        nuclear pore complex protein 98: 236

Experts

1.	Mecucci, Cristina: 12 articles (01/2022 - 05/2002)
2.	Aplan, Peter D: 11 articles (10/2021 - 07/2004)
3.	La Starza, Roberta: 8 articles (07/2015 - 05/2002)
4.	Gorello, Paolo: 7 articles (07/2015 - 12/2004)
5.	Humphries, R Keith: 6 articles (04/2011 - 03/2004)
6.	Di Giacomo, Danika: 5 articles (01/2022 - 03/2013)
7.	Hayashi, Yasuhide: 5 articles (02/2016 - 01/2002)
8.	Yaseen, Nabeel R: 5 articles (08/2014 - 01/2004)
9.	Nakamura, Takuro: 5 articles (05/2011 - 01/2002)
10.	Martelli, Massimo F: 5 articles (09/2009 - 05/2002)

Related Diseases

1.	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 10/09/2014 - "In this issue of Blood, Ostronoff et al report a low remission rate in acute myeloid leukemia (AML) patients coexpressing FLT3/ITD and cryptic translocation t(5;11)(q35;p15.5), known as NUP98/NSD1." 01/01/2003 - "The present results, together with previous studies of NUP98/homeobox gene fusions, strongly indicate that NUP98/HOXC13 is of pathogenetic importance in t(11;12)-positive acute myeloid leukemia." 10/01/2023 - "The cryptic fusion oncogene NUP98::NSD1 is known to be associated with FLT3-ITD mutation in acute myeloid leukemia (AML), and an independent poor prognostic factor in pediatric AML. " 09/19/2023 - "Clinical and Biological Characteristics of 14 NUP98-NSD1+ Adult Acute Myeloid Leukemia Patients." 08/01/2023 - "The NUP98::NSD1 fusion gene is associated with extremely poor prognosis in patients with acute myeloid leukemia (AML). "
2.	Acute Promyelocytic Leukemia 05/01/2015 - "Here, we showed that homodimeric NUP98-RARG not only acquired unique nuclear localization pattern and ability of recruiting both RXRA and wild-type NUP98, but also exhibited similar transcriptional properties as RARA fusions found in acute promyelocytic leukemia (APL). " 12/01/2023 - "Acute myeloid leukemia with NUP98::RARG resembling acute promyelocytic leukemia accompanying ARID1B gene mutation." 11/23/2023 - "Acute myeloid leukemia with NUP98::HOXA9 mimicking acute promyelocytic leukemia." 01/01/2022 - "A Novel NUP98/RARG Gene Fusion in Pediatric Acute Myeloid Leukemia Resembling Acute Promyelocytic Leukemia." 01/06/2011 - "A novel NUP98/RARG gene fusion in acute myeloid leukemia resembling acute promyelocytic leukemia."
3.	BCR-ABL Positive Chronic Myelogenous Leukemia (Chronic Myelogenous Leukemia) 04/01/2001 - "NUP98 gene rearrangements and the clonal evolution of chronic myelogenous leukemia." 01/01/2021 - "In this study, a murine model of blast crisis chronic myelogenous leukemia (bcCML) that expresses the translocation products BCR/ABL and Nup98/HoxA9 was used to determine the role of CCL3 in BMME regulation. " 01/01/2014 - "Blast crisis Ph+ chronic myeloid leukemia with NUP98/HOXA13 up-regulating MSI2." 05/01/2006 - "The formation of fusion genes between NUP98 and members of the HOX family represents a critical factor for the genesis of acute leukemia or acute transformation of chronic myeloid leukemia (CML). " 03/01/2005 - "Clonal evolution with inv(11)(p15q22) and NUP98/DDX10 fusion gene in imatinib-resistant chronic myelogenous leukemia."
4.	Neuroblastoma 05/01/2017 - "Subsequent molecular and sequencing analysis demonstrated a NUP98-HOXA9 fusion gene with a type I fusion between NUP98 exon 12 and HOXA9 exon 1b, and mutations in neuroblastoma V-Ras oncogene homolog and Wilms tumor 1. The patient achieved hematological complete remission (CR) following two courses of induction chemotherapy. " 01/01/2021 - "We describe a patient with MPAL with a NUP98 (nucleoporin 98)-NSD1 gene fusion (nuclear receptor binding SET domain protein1) and NRAS (neuroblastoma RAS viral oncogene homolog mutation) p.Gly61Arg mutation who was treated with upfront AML-based chemotherapy, received hematopoietic stem cell transplant (HSCT), but unfortunately died from relapsed disease. "
5.	Wilms Tumor (Wilm's Tumor) 05/01/2017 - "Subsequent molecular and sequencing analysis demonstrated a NUP98-HOXA9 fusion gene with a type I fusion between NUP98 exon 12 and HOXA9 exon 1b, and mutations in neuroblastoma V-Ras oncogene homolog and Wilms tumor 1. The patient achieved hematological complete remission (CR) following two courses of induction chemotherapy. "

Related Drugs and Biologics

1.	Alkaloids
2.	Nuclear Pore Complex Proteins (Nucleoporins)
3.	Proteins (Proteins, Gene)
4.	Protein Isoforms (Isoforms)
5.	Phenylalanine (L-Phenylalanine)
6.	Glycine (Aminoacetic Acid)
7.	deguelin
8.	Glutamic Acid (Glutamate)
9.	Complementary DNA (cDNA)
10.	Threonine (L-Threonine)

Related Therapies and Procedures

1.	Therapeutics
2.	Induction Chemotherapy
3.	Hematopoietic Stem Cell Transplantation
4.	Drug Therapy (Chemotherapy)
5.	Peripheral Blood Stem Cell Transplantation (Peripheral Stem Cell Transplantation)