cystic fibrosis transmembrane conductance regulator delta F508

CFTR - Cystic Fibrosis Transmembrane conductance regulator (a plasma membrane chloride channel); has mutation deletion of phenylalanine at residue 508; associated with cystic fibrosis

Also Known As:

Networked: 24 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Verkman, A S: 5 articles (01/2010 - 09/2004)
2.	Kurth, Mark J: 2 articles (01/2010 - 10/2008)
3.	Yang, Baoxue: 2 articles (01/2010 - 10/2008)
4.	Becq, Frédéric: 2 articles (05/2007 - 05/2006)
5.	Galietta, Luis J V: 2 articles (01/2006 - 09/2004)
6.	Haston, Christina K: 1 article (07/2010)
7.	Paradis, Josée: 1 article (07/2010)
8.	Wilke, Martina: 1 article (07/2010)
9.	Butler, Jeffrey D: 1 article (01/2010)
10.	Mills, Aaron D: 1 article (01/2010)

Related Diseases

1.	Cystic Fibrosis (Mucoviscidosis) 05/29/2009 - "The cystic fibrosis (CF)-causing mutant, deltaF508-CFTR, is misfolded and fails to traffic out of the endoplasmic reticulum (ER) to the cell surface. " 04/01/2009 - "When BHK cells were incubated at 29 degrees C to rescue DeltaF508-CFTR trafficking, and then biotinylated and sorted to remove permeable cells, labelling of core-glycosylated DeltaF508-CFTR was no longer detected although a weak signal was still observed using CFBE (cystic fibrosis bronchial epithelial) cells. " 09/23/2008 - "The relatively weak affinity of the CAL:CFTR interaction may provide a pharmacological window for stabilizing rescued DeltaF508-CFTR in patients with cystic fibrosis." 08/15/2008 - "Mild processing defect of porcine DeltaF508-CFTR suggests that DeltaF508 pigs may not develop cystic fibrosis disease." 06/01/2008 - "Chemical rescue of deltaF508-CFTR mimics genetic repair in cystic fibrosis bronchial epithelial cells."
2.	Pancreatic Diseases (Pancreatic Disease) 08/15/2008 - "Recent efforts have made significant progress in generating transgenic pigs with the DeltaF508-CFTR mutation to model the lung and pancreatic disease of human cystic fibrosis. "
3.	Inflammation (Inflammations) 02/01/2002 - "However, the molecular mechanism by which the deltaF508-CFTR protein facilitates pulmonary infection and inflammation remains unclear. "
4.	Infections 02/01/2002 - "However, the molecular mechanism by which the deltaF508-CFTR protein facilitates pulmonary infection and inflammation remains unclear. "
5.	Bone Diseases (Bone Disease) 07/01/2010 - "An osteopenic bone disease is evident in adult DeltaF508-Cftr cystic fibrosis mouse models."

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	Curcumin
3.	Mutant Proteins (Protein, Mutant)
4.	Casein Kinase II (Casein Kinase 2)
5.	Ubiquitin
6.	Genistein
7.	Cystic Fibrosis Transmembrane Conductance Regulator (Protein, CFTR)
8.	NF-kappa B (NF-kB)
9.	Phenylalanine (L-Phenylalanine)
10.	Isoflavones

Related Therapies and Procedures

1.	Therapeutics