|1.||Kloog, Yoel: 32 articles (10/2015 - 02/2002)|
|2.||Haklai, Roni: 11 articles (10/2014 - 06/2003)|
|3.||Elad-Sfadia, Galit: 7 articles (10/2015 - 06/2003)|
|4.||Haklai, Ronit: 6 articles (10/2015 - 02/2002)|
|5.||Reif, Shimon: 5 articles (10/2014 - 08/2004)|
|6.||Ling, Yong: 4 articles (05/2014 - 05/2010)|
|7.||Rechavi, Gideon: 4 articles (05/2010 - 06/2005)|
|8.||Yue, Wei: 4 articles (01/2008 - 01/2005)|
|9.||Santen, Richard J: 4 articles (01/2008 - 01/2005)|
|10.||Barkan, Batya: 3 articles (02/2013 - 09/2006)|
|1.||Closed Head Injuries
06/01/2003 - "Based on this hypothesis, a new concept of neuroprotection is proposed, examined here by investigating the effect of the Ras inhibitor S-trans, trans-farnesylthiosalicylic acid (FTS) in a mouse model of closed head injury (CHI). "
06/01/2003 - "The Ras inhibitor S-trans, trans-farnesylthiosalicylic acid exerts long-lasting neuroprotection in a mouse closed head injury model."
08/01/2007 - "S-trans-trans-farnesylthiosalicylic acid (FTS), a synthetic Ras inhibitor, acts primarily on the active, GTP-bound form of Ras and was shown to improve neurobehavioral outcome after closed head injury (CHI) in mice. "
03/01/2010 - "The Ras antagonist farnesylthiosalicylic acid ameliorates experimental myocarditis in the rat."
03/01/2010 - "We thus hypothesized that S-farnesylthiosalicylic acid (FTS), a synthetic small molecule that detaches Ras from the inner cell membrane and induces its rapid degradation, will attenuate experimental autoimmune myocarditis (EAM). "
06/01/2010 - "Animal studies demonstrated that salirasib inhibited tumor growth, downregulated gene expression in the cell cycle and Ras signaling pathways. "
10/20/2015 - "Moreover, the reduction in the tumor burden in a mouse model of ES following Salirasib treatment, suggests therapeutic potential for this RAS inhibitor in ES. "
05/01/2014 - "Synthesis and biological evaluation of novel farnesylthiosalicylic acid derivatives for cancer treatment."
01/01/2014 - "Using the Ras inhibitor S-trans,trans-farnesylthiosalicylic acid (FTS), we investigated interplay between HGF/SF-Met-Ras signaling, metabolism, and tumor blood-flow regulation. "
12/01/2012 - "Salirasib inhibited the growth of 2/14 PDX models of PDA and modulated Ras signaling in these tumors. "
|4.||Pancreatic Neoplasms (Pancreatic Cancer)
06/23/2014 - "The 48 h EC50 values for pancreatic cancer Mia PaCa-2 and BxPC-3 cell lines were as low as 1.9 μM while salirasib and farnesylthiosalicylamide were ineffective at 20 μM. "
10/01/2013 - "We synthesized phospho-farnesylthiosalicylic acid (PFTS; MDC-1016) and evaluated its efficacy, safety, and metabolism in preclinical models of pancreatic cancer. "
06/01/2010 - "Salirasib in the treatment of pancreatic cancer."
06/01/2010 - "Future studies will determine whether salirasib adds to the anti-tumor activity of drugs approved by the US FDA for pancreatic cancer."
01/01/2008 - "Salirasib is currently undergoing trials in patients with pancreatic cancer and with nonsmall cell lung cancer, with or without identified K-Ras mutations. "
|5.||Liver Cirrhosis (Hepatic Cirrhosis)
08/01/2004 - "In a previous study in rats, we have shown that a synthetic Ras antagonist, S-farnesylthiosalicylic acid (FTS), could inhibit the development of liver cirrhosis. "
12/01/1999 - "The aim of the present study was to examine whether a synthetic Ras antagonist, S-farnesylthiosalicylic acid (FTS), which specifically dislodges Ras from the membrane of Ras-transformed fibroblasts (EJ cells), can prevent experimentally-induced liver cirrhosis in rats. "
04/01/2008 - "In vivo inhibition of Ras by its antagonist farnesylthiosalicylic acid (FTS) prevents and reverses liver fibrosis in a rat model. "
12/01/1999 - "The Ras antagonist, farnesylthiosalicylic acid (FTS), inhibits experimentally-induced liver cirrhosis in rats."
08/01/2004 - "Treatment of thioacetamide-induced liver cirrhosis by the Ras antagonist, farnesylthiosalicylic acid."
|1.||Guanosine Triphosphate (GTP)
|5.||Nitric Oxide (Nitrogen Monoxide)
|6.||Galectin 1 (LGALS1)
|8.||Proteins (Proteins, Gene)
|1.||Heterologous Transplantation (Xenotransplantation)