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ABT 299

converted in vivo to A-85783.0; a platelet activating factor antagonist; structure in first source

Also Known As:

ABT-299

Networked: 4 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Thiazoles: 392
      - ABT 299: 4
  - Pyridines: 88
    - Pyridinium Compounds: 5
      - ABT 299: 4
Organic Chemicals: 133
- Sulfur Compounds: 278
  - Thiazoles: 392
    - ABT 299: 4

Related Diseases

1.	Hypotension (Low Blood Pressure) 06/01/1996 - "The in vivo generation of A-85783 from ABT-299 leads to potent inhibition of PAF-induced inflammatory responses (increased vascular permeability, hypotension and edema) and PAF-induced lethality. " 08/01/1996 - "ABT-299 (.1 mg/kg) was also effective in preventing hypotension and gastrointestinal damage induced by lipoteichoic acid (LTA), a putative causative agent of shock in Gram-positive infections. "
2.	Shock 08/01/1996 - "These results illustrate the impressive potency and duration of action of ABT-299 and support the putative role of PAF in acute models of endotoxic shock." 08/01/1996 - "ABT-299, a highly potent and selective platelet activating factor (PAF) antagonist, was found to be effective in rat models of endotoxic shock. " 08/01/1996 - "ABT-299 (.1 mg/kg) was also effective in preventing hypotension and gastrointestinal damage induced by lipoteichoic acid (LTA), a putative causative agent of shock in Gram-positive infections. "
3.	Infections 08/01/1996 - "ABT-299 (.1 mg/kg) was also effective in preventing hypotension and gastrointestinal damage induced by lipoteichoic acid (LTA), a putative causative agent of shock in Gram-positive infections. "
4.	Endotoxemia 08/01/1996 - "ABT-299, a novel PAF antagonist, attenuates multiple effects of endotoxemia in conscious rats." 04/01/1996 - "To evaluate the effect of ABT-299 administration during endotoxemia, pigs were randomly assigned to one of three groups: controls (n = 7), LPS (n = 9), or ABT-299 + LPS (n =7). " 05/01/1998 - "To further define the role of platelet-activating factor (PAF) in endotoxin-induced lung dysfunction, we examined the effect of ABT-299, a specific and potent PAF-receptor antagonist, on the response to endotoxemia in six chronically instrumented awake sheep. "
5.	Pulmonary Hypertension 05/01/1998 - "ABT-299 was shown to completely block the pulmonary hypertension and reduction in Cdyn seen after intravenous administration of exogenous PAF. " 04/01/1996 - "ABT-299 reduced the early LPS-induced fall in cardiac index and stroke volume, pulmonary hypertension and vasoconstriction, bronchoconstriction, and hypoxemia. "

Related Drugs and Biologics

1.	Platelet Activating Factor
2.	lipoteichoic acid
3.	Prothrombin (Factor II)
4.	Fibrinogen (Factor I)
5.	Fibrin Fibrinogen Degradation Products
6.	Endotoxins
7.	Dacarbazine (DIC)
8.	A 85783.0

Related Therapies and Procedures

1.	Intravenous Administration