benzyloxycarbonyl- Asp- CH2OC(O)- 2,6- dichlorobenzene

inhibits interleukin-1beta-converting enzyme (ICE); prevents antitumor agent-induced apoptosis in human myeloid leukemia U937 cells; also a caspase inhibitor

Also Known As:

Networked: 8 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Han, Seung Hyeok: 1 article (08/2015)
2.	Kang, Hye-Young: 1 article (08/2015)
3.	Kang, Shin-Wook: 1 article (08/2015)
4.	Kim, Chan Ho: 1 article (08/2015)
5.	Kim, Seonghun: 1 article (08/2015)
6.	Lee, Mi Jung: 1 article (08/2015)
7.	Lee, Sun Ha: 1 article (08/2015)
8.	Moon, Sung Jin: 1 article (08/2015)
9.	Nam, Bo Young: 1 article (08/2015)
10.	Oh, Hyung Jung: 1 article (08/2015)

Related Diseases

1.	Hypoxia (Hypoxemia) 09/01/1999 - "In the proximal tubules, Z-D-DCB also inhibited the hypoxia-induced increase in calpain activity, another cysteine protease. " 09/01/1999 - "The specific caspase inhibitor Z-Asp-2,6-dichlorobenzoyloxymethylketone (Z-D-DCB) attenuated the increase in caspase activity during 15 min of hypoxia and markedly decreased lactate dehydrogenase release in a dose-dependent manner. " 11/13/1998 - "Pretreatment with Z-Asp-CH2-DCB, a caspase inhibitor, suppressed the DNA ladder in response to hypoxia in a concentration-dependent manner. " 02/01/2001 - "The broad caspase inhibitor Z-Asp-CH2-DCB prevents the development of intravascular pulmonary endothelial cell growth and severe pulmonary hypertension caused by the combination of SU5416 and chronic hypoxia."
2.	Necrosis 05/01/2002 - "Simultaneously with neuronal differentiation, substantial apoptosis and necrosis/type 2 physiological cell death, which is independent of apoptosis and resistant to a broad-spectrum caspase inhibitor, Z-Asp-CH2-DCB, were also observed. "
3.	Myeloid Leukemia (Leukemia, Myelocytic) 04/26/1995 - "We found that a novel protease inhibitor, benzyloxycarbonyl-Asp-CH2OC(O)-2,6-dichlorobenzene (Z-Asp-CH2-DCB), which can preferentially inhibit interleukin-1 beta-converting enzyme (ICE), completely blocked the apoptotic cell death of human myeloid leukemia U937 cells caused by etoposide, camptothecin, 1-beta-D-arabinofuranosyl-cytosine and Adriamycin, as well as TNF-alpha, anti-Fas antibody and staurosporine. "
4.	Hypertrophy 08/01/2015 - "Hypertrophy and apoptosis were inhibited using an epidermal growth factor receptor inhibitor (PKI 166) and a pan-caspase inhibitor (zAsp-DCB), respectively. "
5.	Pulmonary Hypertension 02/01/2001 - "The broad caspase inhibitor Z-Asp-CH2-DCB prevents the development of intravascular pulmonary endothelial cell growth and severe pulmonary hypertension caused by the combination of SU5416 and chronic hypoxia."

Related Drugs and Biologics

1.	Caspases
2.	DNA (Deoxyribonucleic Acid)
3.	ErbB Receptors (EGF Receptor)
4.	Cysteine Proteases (Cysteine Protease)
5.	Interleukin-1beta (Interleukin 1 beta)
6.	Extracellular Signal-Regulated MAP Kinases (Extracellular Signal Regulated Kinases)
7.	Mitogen-Activated Protein Kinases
8.	Staurosporine
9.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
10.	RNA (Ribonucleic Acid)