NK-lysin

a 78-residue peptide from porcine small intestine; has antimicrobial & tumorolytic properties; homologous to SP-B & belongs to the family of saposin-like proteins; amino acid sequence given in first source

Networked: 44 relevant articles (6 outcomes, 3 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Lillehoj, Hyun S: 3 articles (10/2021 - 04/2006)
2.	Fan, Kuohai: 3 articles (11/2019 - 01/2016)
3.	Li, Hongquan: 3 articles (11/2019 - 01/2016)
4.	Andrä, Jörg: 3 articles (04/2013 - 11/2005)
5.	Min, Wongi: 2 articles (10/2021 - 04/2006)
6.	Cuesta, Alberto: 2 articles (01/2021 - 01/2020)
7.	Guzmán, Fanny: 2 articles (01/2021 - 01/2020)
8.	Valero, Yulema: 2 articles (01/2021 - 01/2020)
9.	Khan, Ajab: 2 articles (11/2019 - 01/2019)
10.	Sun, Yaogui: 2 articles (11/2019 - 01/2016)

Related Diseases

1.	Infections 09/01/2021 - "A novel NK-lysin in hybrid crucian carp can exhibit cytotoxic activity in fish cells and confer protection against Aeromonas hydrophila infection in comparison with Carassius cuvieri and Carassius auratus red var." 07/01/2013 - "In this study, we identified a NK-lysin, CsNKL1, from half-smooth tongue sole (Cynoglossus semilaevis) and analyzed its expression, genetic organization, and biological effect on pathogen infection. " 10/01/2023 - "albiflora's resistance to V. harveyi infection and provide new insights into the crucial role of NK-lysin in the innate immunity of teleost fishes." 09/01/2021 - "NK-lysin, an effector of natural killer (NK) cells and cytotoxic T lymphocytes (CTLs), not only exhibits cytotoxic effect in fish cells, but also participates in the immune defense against pathogenic infection. " 01/01/2021 - "Barbel steed (Hemibarbus labeo) NK-lysin protects against Aeromonas hydrophila infection via immunomodulatory activity."
2.	Hepatocellular Carcinoma (Hepatoma) 11/01/2019 - "Recombinant porcine NK-lysin inhibits the invasion of hepatocellular carcinoma cells in vitro." 01/01/2019 - "We analyzed the anti-invasion and antimetastatic effects of porcine recombinant NK-lysin, which was designed and expressed in vitro by our research group, on SMMC-7721 hepatocellular carcinoma cells via wound-healing assays, adhesion assays, invasion assays, real-time polymerase chain reaction (PCR), and Western blot analysis. " 01/01/2019 - "Anti-Invasion and Antimetastatic Effects of Porcine Recombinant NK-lysin on SMMC-7721 Human Hepatocellular Carcinoma Cells." 07/20/2023 - "[Procine recombinant NK-lysin inhibits hepatocellular carcinoma metastasis by downregulating FKBP3 and inhibiting oxidative phosphorylation and glycolysis: a proteomic analysis]." 01/01/2016 - "The results showed that the recombinant porcine NK-lysin possesses potent antitumor activity against the human hepatocellular carcinoma cell line SMMC-7721 in a time- and dose-dependent manner, but has negligible hemolysis activity against human erythrocytes. "
3.	Breast Neoplasms (Breast Cancer) 01/01/2022 - "Promising results from in vitro experimental studies using docosahexaenoic acid (DHA) in breast cancer and recombinant porcine NK-lysin A in hepatocellular carcinoma have revealed that anticancer drugs targeting FSCN1 have significant potential clinical applications. "
4.	Coccidiosis 10/01/2021 - "Expression of Chicken NK-Lysin and Its Role in Chicken Coccidiosis Induced by Eimeria necatrix." 04/15/2006 - "Following intestinal infection of chickens with Eimeria maxima, one of seven Eimeria species causing avian coccidiosis, NK-lysin transcript levels increased 3-4-fold in CD4+ and CD8+ intestinal IELs. " 10/18/2013 - "We previously expressed and purified a full-length chicken NK-lysin (cNKL) recombinant protein, and demonstrated its in vitro anti-parasitic activity against the apicomplexan protozoan, Eimeria, the etiologic agent of avian coccidiosis. " 10/01/2021 - "Coccidiosis in chickens is an intestinal parasitic disease caused by protozoan parasites named Eimeria spp. In some Eimeria infections, intestinal lymphocytes are known to highly express chicken NK-lysin (cNK-lysin), an antimicrobial peptide with anticoccidial activity. " 05/01/2023 - "Oral administration of chicken NK-lysin or recombinant chicken IL-7 improves vaccine efficacy of Eimeria tenella elongation factor-1α (EF-1α) against coccidiosis in commercial broiler chickens."
5.	Bacterial Infections (Bacterial Infection) 02/01/2018 - "Nevertheless, the implication of NK-lysin in the protection against bacterial infection is not aware in common carp. " 09/01/2021 - "These results indicated that NK-lysin in hybrid fish contained close sequence similarity to those of its parents, possessing the capacities of cytotoxicity and immune defense against bacterial infection."

Related Drugs and Biologics

1.	Peptides (Polypeptides)
2.	Interleukin-7 (Interleukin 7)
3.	Docosahexaenoic Acids
4.	Vaccines
5.	Proteins (Proteins, Gene)
6.	Antimicrobial Peptides
7.	Hepcidins
8.	Granzymes (Granzyme)
9.	Messenger RNA (mRNA)
10.	Saposins

Related Therapies and Procedures

1.	Oral Administration
2.	Aftercare (After-Treatment)