|1.||Sen, Subrata: 16 articles (04/2014 - 03/2003)|
|2.||Ecsedy, Jeffrey A: 12 articles (12/2015 - 03/2007)|
|3.||Ecsedy, Jeffrey: 10 articles (12/2013 - 11/2008)|
|4.||Liu, Quentin: 9 articles (01/2015 - 03/2008)|
|5.||El-Rifai, Wael: 9 articles (01/2015 - 04/2008)|
|6.||Katayama, Hiroshi: 9 articles (02/2012 - 12/2003)|
|7.||Li, Yan: 8 articles (07/2015 - 08/2008)|
|8.||Coumar, Mohane Selvaraj: 8 articles (01/2015 - 03/2009)|
|9.||Fingert, Howard: 8 articles (12/2014 - 10/2010)|
|10.||Moll, Jürgen: 8 articles (09/2012 - 09/2007)|
02/01/2012 - "Aurora Kinase (AK) based therapy targeting AK-A & B is effective against some cancers. "
04/01/2011 - "In conclusion, our data demonstrated that Aurora kinase inhibition is effective in reducing cell growth and inducing apoptosis of ATC in vitro and tumor growth and vascularity in vivo. "
01/01/2010 - "Therefore, Aurora kinase inhibitors should be useful in the treatment of cancers. "
10/23/2008 - "PTTG1 knockdown is therefore a potential approach to improve the efficacy of tumor Aurora kinase inhibitors."
05/15/2013 - "NEDD9 depletion destabilizes Aurora A kinase and heightens the efficacy of Aurora A inhibitors: implications for treatment of metastatic solid tumors."
|2.||Ovarian Neoplasms (Ovarian Cancer)
01/01/2013 - "Targeting epigenetics with the HDAC inhibitor, in combination with Aurora kinase inhibitors, holds promise for more effective therapy of ovarian cancer."
09/01/2008 - "The role of Aurora kinase inhibition in ovarian cancer merits further investigation in clinical trials."
01/01/2008 - "We show that inhibition of the Aurora kinases prevents phosphorylation of a mitotic marker and demonstrate a dose-dependent increase of apoptosis in treated ovarian cancer cells. "
07/15/2007 - "Aurora-A kinase is overexpressed by a substantial proportion of ovarian cancers and is associated with centrosome amplification and poor survival. "
07/15/2007 - "Aurora-A kinase expression was assessed by Western blot (cell lines) or immunohistochemistry (high-grade epithelial ovarian cancers), and clinical variables were collected by retrospective chart review. "
|3.||Acute Myeloid Leukemia (Acute Myelogenous Leukemia)
06/01/2007 - "A novel treatment strategy targeting Aurora kinases in acute myelogenous leukemia."
03/01/2010 - "In this study, we report the effects of AZD1152-HQPA, a highly selective inhibitor of aurora-B kinase, in acute myeloid leukemia (AML) cell lines and primary samples. "
12/01/2013 - "We previously showed that Aurora kinase A (AURKA) is aberrantly expressed in acute myelogenous leukemia (AML) cells when compared to bone marrow mononuclear cells isolated from healthy volunteers. "
12/01/2013 - "CD34⁺/CD38⁻ acute myelogenous leukemia cells aberrantly express Aurora kinase A."
03/01/2010 - "The FLT3 internal tandem duplication mutation is a secondary target of the aurora B kinase inhibitor AZD1152-HQPA in acute myelogenous leukemia cells."
06/01/2007 - "Taken together, inhibition of Aurora kinases may be a promising treatment strategy for individuals with leukemia."
01/29/2015 - "This review will describe the functions of each Aurora kinase, summarize their involvement in leukemia and discuss inhibitor development and efficacy in leukemia clinical trials. "
01/29/2015 - "Several early studies found that Aurora kinases are amplified and overexpressed at the transcript and protein level in various malignancies, including several types of leukemia. "
01/01/2014 - "A comparative analysis of these agents in cytotoxicity and target modulation analyses against a panel of leukemia cells provides novel insights into the unique mechanisms and codependent activity pathways involved in targeting Aurora kinases, constituting a distinctive preclinical experimental framework to identify appropriate agents and combinations in future clinical studies. "
07/01/2012 - "Aurora kinase inhibitors are in early clinical trials for the treatment of leukemia. "
|5.||Breast Neoplasms (Breast Cancer)
08/01/2015 - "To the best of our knowledge, this is the first study to show that Aurora kinases are key molecules in PKC-induced invasion in breast cancer cells."
08/01/2015 - "However, few studies have assessed the effect of Aurora kinases in breast cancer. "
05/01/2015 - "p53 Family Members Regulate Phenotypic Response to Aurora Kinase A Inhibition in Triple-Negative Breast Cancer."
01/01/2015 - "The pan-inhibitor of Aurora kinases danusertib induces apoptosis and autophagy and suppresses epithelial-to-mesenchymal transition in human breast cancer cells."
09/15/2014 - "Aurora kinase a suppresses metabolic stress-induced autophagic cell death by activating mTOR signaling in breast cancer cells."
|1.||2- ((3- ((4- ((5- (2- ((3- fluorophenyl)amino)- 2- oxoethyl)- 1H- pyrazol- 3- yl)amino)quinazolin- 7- yl)oxy)propyl)(ethyl)amino)ethyl dihydrogen phosphate
|8.||Proteins (Proteins, Gene)
|9.||4- (4- (N- benzoylamino)anilino)- 6- methoxy- 7- (3- (1- morpholino)propoxy)quinazoline
|1.||Heterologous Transplantation (Xenotransplantation)
|2.||Drug Therapy (Chemotherapy)