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2-chloro-4-methylthiobutanoic acid

isolated from salt-nitrite-treated Sanma hiraki fish; structure given in first source

Also Known As:

2-Cl-4-MTBA; 2-chloro-4-methylthiobutanoate

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Carboxylic Acids: 973
  - Acyclic Acids
    - Butyrates: 2613
      - 2-chloro-4-methylthiobutanoic acid: 2
- Sulfur Compounds: 278
  - Sulfhydryl Compounds: 4168
    - 2-chloro-4-methylthiobutanoic acid: 2
Lipids: 114793
- Fatty Acids: 27405
  - Volatile Fatty Acids: 3052
    - Butyrates: 2613
      - 2-chloro-4-methylthiobutanoic acid: 2

Related Diseases

1.	Carcinogenesis 01/01/1996 - "While N-nitroso compounds were generally believed to be associated with gastric carcinogenesis, it was unexpectedly found that the mutagen has the novel structure 2-chloro-4-methylthiobutanoic acid (CMBA). " 01/01/1996 - "Gastric carcinogenesis: 2-chloro-4-methylthiobutanoic acid, a novel mutagen in salted, pickled Sanma hiraki fish, or similarly treated methionine."
2.	Necrosis 11/12/1996 - "2-Chloro-4-methylthiobutanoic acid (CMBA, a mutagen from Japanese salted fish) at 15-500 mg/kg body weight induced several-fold increase in replicative DNA synthesis (RDS) (P < 0.05) after 80 min and 17 h, equivocal unscheduled DNA synthesis (UDS) after 80 min and necrosis 80 min after its administration in the stomach pyloric mucosa of F344 and ACI male rats. "
3.	Body Weight (Weight, Body) 11/12/1996 - "2-Chloro-4-methylthiobutanoic acid (CMBA, a mutagen from Japanese salted fish) at 15-500 mg/kg body weight induced several-fold increase in replicative DNA synthesis (RDS) (P < 0.05) after 80 min and 17 h, equivocal unscheduled DNA synthesis (UDS) after 80 min and necrosis 80 min after its administration in the stomach pyloric mucosa of F344 and ACI male rats. "

Related Drugs and Biologics

1.	Mutagens
2.	Nitroso Compounds
3.	Methionine (L-Methionine)
4.	DNA (Deoxyribonucleic Acid)