HOME
PRODUCTS
COMPANY
CONTACT
FAQ
Research
Dictionary
Pharma
Sign Up
FREE
or
Login
Username:
Password:
Remember login
Login
Send password reminder...
9- (3- (2- nitro- 1- imidazolyl)propylamino)- 1,2,3,4- tetrahydroacridine
RN refers to HCl; structure given in first source
Also Known As:
THNLA-1
Networked:
3
relevant articles (
0
outcomes,
1
trials/studies)
Bio-Agent Context: Research Results
Heterocyclic Compounds: 198
Fused-Ring Heterocyclic Compounds
3-Ring Heterocyclic Compounds
Acridines: 325
Aminoacridines: 3
Tacrine: 772
9-(3-(2-nitro-1-imidazolyl)propylamino)-1,2,3,4-tetrahydroacridine: 3
Related Diseases
1.
Neoplasms (Cancer)
01/01/1996 - "
Toxicity studies in balb/c mice (without tumors) showed that THNLA-1 is well tolerated up to at least 70 mg/kg for more than 40 days while no toxicity was observed with the combined drugs used in our experimental protocol.
"
2.
Hypoxia (Hypoxemia)
01/01/1999 - "
Finally, potential lethal damage repair was totally suppressed only in the hypoxia-pretreated cells with THNLA-1.
"
01/01/1999 - "
Significantly increased apoptosis was observed in the hypoxia-pretreated cells with THNLA-1, 12 and 24 h posttreatment.
"
01/01/1996 - "
The supra-additive effect is dependent on the hypoxia-pretreatment time with THNLA-1, on THNLA-1 concentration and on the concentration of the chemotherapeutic drug.
"
01/01/1999 - "
Comet and alkaline elution assay analysis showed increased DNA cross-links in the hypoxia-pretreated cells with THNLA-1 compared to the L-PAM-alone-treated cells.
"
01/01/1994 - "
THNLA-1 is a good hypoxia-selective cytotoxin with a differential toxicity of approximately equal to 11 in V79 cells, but it is approximately equal to 2 times less potent on a concentration basis than NLA-1 (the 2-nitroimidazole linked acridine analog).
"
Related Drugs and Biologics
1.
Nitroimidazoles
2.
Melphalan (Alkeran)
3.
DNA (Deoxyribonucleic Acid)
4.
Cytotoxins (Cytolysins)
5.
Acridines
6.
NLA 1