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CP 77059

a quinazolinedione; a phosphodiesterase-IV (PDE-IV) inhibitor; structure given in first source

Also Known As:

CP-77059; CP77059

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Quinazolines: 402
      - CP 77059: 1

Related Diseases

1.	Shock 04/01/1995 - "In LPS-induced endotoxic shock, rolipram and CP-77059 at relatively high doses of 30 and 10 mg/kg, respectively, significantly reduced serum TNF-alpha levels, and also inhibited mortality 66%. "
2.	Inflammation (Inflammations) 04/01/1995 - "In the adjuvant arthritis model, a chronic model of inflammation also possessing localized TNF-alpha elevation in the inflamed paw, rolipram and CP-77059 suppressed ankle swelling and radiological evidence of joint damage. "
3.	Experimental Arthritis 04/01/1995 - "In the adjuvant arthritis model, a chronic model of inflammation also possessing localized TNF-alpha elevation in the inflamed paw, rolipram and CP-77059 suppressed ankle swelling and radiological evidence of joint damage. "

Related Drugs and Biologics

1.	Rolipram
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