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N- alpha- DTPA- tyrosyl- N- epsilon- DTPA- lysine

Also Known As:

111In-di-DTPA-TL; di-DTPA-TL

Networked: 2 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Peptides: 82426
  - Oligopeptides: 519
    - Dipeptides: 945
      - N-alpha-DTPA-tyrosyl-N-epsilon-DTPA-lysine: 2
Organic Chemicals: 133
- Amines: 4871
  - Polyamines: 3918
    - Pentetic Acid: 1751
      - N-alpha-DTPA-tyrosyl-N-epsilon-DTPA-lysine: 2
- Carboxylic Acids: 973
  - Acyclic Acids
    - Acetates: 4994
      - Pentetic Acid: 1751
        N-alpha-DTPA-tyrosyl-N-epsilon-DTPA-lysine: 2

Related Diseases

1.	Neoplasms (Cancer) 01/01/1999 - "The time required for the tumor to double in size was respectively 57 and 86 d with 37 and 92.5 MBq F6-734/131I-di-DTPA-TL and 44 and 65 d with 37 and 92.5 MBq 131I-F6. " 04/01/1995 - "In patients with colorectal or medullary thyroid cancer, clinical studies performed with an anti-CEA/anti-DTPA-indium bifunctional antibody and an indium-111-labeled di-DTPA-TL bivalent hapten showed that tumor uptake was not modified compared to results for F(ab')2 fragments of the same anti-CEA antibody directly labeled with indium-111, whereas the radioactivity of normal tissues was significantly reduced (3- to 6-fold). "
2.	medullary Thyroid cancer 04/01/1995 - "In patients with colorectal or medullary thyroid cancer, clinical studies performed with an anti-CEA/anti-DTPA-indium bifunctional antibody and an indium-111-labeled di-DTPA-TL bivalent hapten showed that tumor uptake was not modified compared to results for F(ab')2 fragments of the same anti-CEA antibody directly labeled with indium-111, whereas the radioactivity of normal tissues was significantly reduced (3- to 6-fold). "
3.	Weight Loss (Weight Reduction) 01/01/1999 - "Weight loss was 5%, leukocyte nadirs respectively 1640+/-838 and 1560+/-1160/mm3 and platelet nadirs 1.46+/-0.52 10(6)/mm3 and 0.73+/-0.38 10(6)/mm3 after injections of 37 and 92.5 MBq F6-734/1311-di-DTPA-TL. "
4.	Melanoma (Melanoma, Malignant) 01/01/1999 - "Four control groups were treated respectively with (a) 92.5 MBq nonspecific 131I-734 fragments, (b) 92.5 MBq 131I-di-DTPA-TL 48 h after injection of a mixture of irrelevant F6-679 (anti-CEA/anti-histamine) and G7A5-734 (anti-melanoma/anti-DTPA) BsMAb, (c) 250 microg nonradiolabeled F6, and 250 microg F6-734 BsMAb and then 48 h later 1.25 nmol of nonradiolabeled hapten. "

Related Drugs and Biologics

1.	Haptens
2.	Pentetic Acid (DTPA)
3.	Indium
4.	Indium-111
5.	Histamine (Histamine Dihydrochloride)

Related Therapies and Procedures

1.	Injections