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IEM 1754

structure given in first source

Also Known As:

1-ammonio-5-(1-adamantanemethylammonio)pentane dibromide; IEM-1754

Networked: 4 relevant articles (2 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Gmiro, V E: 3 articles (05/2007 - 06/2000)
2.	Lukomskaia, N Ia: 2 articles (05/2013 - 06/2000)
3.	Magazanik, L G: 1 article (05/2013)
4.	Oganesian, G A: 1 article (05/2013)
5.	Vataev, S I: 1 article (05/2013)
6.	Serdyuk, S E: 1 article (05/2007)
7.	Lukomskaya, N Y: 1 article (09/2000)
8.	Zhabko, E P: 1 article (09/2000)
9.	Gorbunova, L V: 1 article (06/2000)
10.	Rukoiatkina, N I: 1 article (06/2000)

Related Diseases

1.	Seizures (Absence Seizure) 05/01/2007 - "Intramuscular injection of IEM-1754, a blocker of cerebral GluR1 AMPA receptors, in doses of 0.5-3.0 mg/kg decreased the incidence of kainate-induced tonic-clonic seizures and mortality rate by 2.7-4 times. "
2.	Catalepsy 06/01/2000 - "A long-term akinesia induced by haloperidol used as an experimental model of catalepsy helped to reveal that a dicationic derivatives adamantane (IEM-1754) and phenylcyclohexyl (IEM-1925) exerted different degrees of inhibition of the haloperidol effect: the IEM-1754 proved to be not inferior to the most effective NMDA antagonist MK-801. "
3.	Sleep Deprivation 05/01/2013 - "Injection of IEM-1754 and IEM-1925 on background of sleep deprivation did not affect the organization of sleep during the first 3 hours of their action. "
4.	Movement Disorders (Movement Disorder) 09/01/2000 - "The ability of the selective non-competitive NMDA receptor blocker MK-801 and a series of new glutamate antagonists --the adamantane derivatives IEM-1754 and IEM-1857 and phencyclidine (IEM-1925)--to prevent movement disorders induced by reversive rotation in mice was studied. "

Related Drugs and Biologics

1.	Dizocilpine Maleate (Dizocilpine)
2.	Adamantane
3.	AMPA Receptors (AMPA Receptor)
4.	N-Methylaspartate (NMDA)
5.	Kainic Acid (Kainate)
6.	Haloperidol (Haldol)
7.	Excitatory Amino Acid Antagonists
8.	N-Methyl-D-Aspartate Receptors (NMDA Receptors)
9.	Phencyclidine (Angel Dust)
10.	IEM 1925

Related Therapies and Procedures

1.	Intramuscular Injections