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TCV 295
a potassium channel opener; structure given in first source
Also Known As:
2-(6-bromo-7-chloro-2,2-dimethyl-2H-1,3-benzoxazin-4-yl)pyridine 1-oxide; TCV-295
Networked:
1
relevant articles (
0
outcomes,
1
trials/studies)
Bio-Agent Context: Research Results
Heterocyclic Compounds: 198
1-Ring Heterocyclic Compounds
Oxazines: 9
Benzoxazines: 58
TCV 295: 1
Fused-Ring Heterocyclic Compounds
2-Ring Heterocyclic Compounds
Benzoxazines: 58
TCV 295: 1
Heterocyclic Oxides
Cyclic N-Oxides: 3
TCV 295: 1
Related Diseases
1.
Hypertension (High Blood Pressure)
12/01/1994 - "
In a 4-week chronic dosing study in SHR, TCV-295 (0.3 mg/kg/day p.o.) produced neither potentiation nor tolerance to its antihypertensive action and no rebound hypertension occurred when drug treatment was discontinued.
"
2.
Tachycardia (Tachyarrhythmias)
12/01/1994 - "
The antihypertensive effects induced by TCV-295 lasted much longer than those of levcromakalim and nisoldipine, and the reflex tachycardia it evoked was less marked than that evoked by these drugs as compared at doses showing similar maximal hypotensive effects.
"
Related Drugs and Biologics
1.
Antihypertensive Agents (Antihypertensives)
2.
Cromakalim (Levcromakalim)
3.
Nisoldipine