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6- N,N- diethyl- beta,gamma- dibromomethylene- D- ATP

an inhibitor of ecto-ATPase

Also Known As:

AR C67156; AR-C67156; ARL 67156; ARL-67156; ARL67156; FPL 67156; FPL-67156

Networked: 12 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Purines: 651
      - Purine Nucleotides: 140
        Adenine Nucleotides: 1066
        Adenosine Triphosphate: 27668
        6-N,N-diethyl-beta,gamma-dibromomethylene-D-ATP: 12
Nucleic Acids, Nucleotides, and Nucleosides: 1
- Nucleotides: 15763
  - Ribonucleotides: 307
    - Adenine Nucleotides: 1066
      - Adenosine Triphosphate: 27668
        6-N,N-diethyl-beta,gamma-dibromomethylene-D-ATP: 12
  - Purine Nucleotides: 140
    - Adenine Nucleotides: 1066
      - Adenosine Triphosphate: 27668
        6-N,N-diethyl-beta,gamma-dibromomethylene-D-ATP: 12

Experts

1.	Fu, Juan: 1 article (01/2022)
2.	Kucera, Gregory L: 1 article (01/2022)
3.	Mao, Chengqiong: 1 article (01/2022)
4.	Ming, Xin: 1 article (01/2022)
5.	Porosnicu, Mercedes: 1 article (01/2022)
6.	Thomas, Alexandra: 1 article (01/2022)
7.	Tian, Shaomin: 1 article (01/2022)
8.	Votanopoulos, Konstantinos I: 1 article (01/2022)
9.	Yeh, Stacy: 1 article (01/2022)
10.	Villa-Bellosta, Ricardo: 1 article (11/2019)

Related Diseases

1.	Vascular Calcification 11/19/2019 - "By contrast, combined treatment with ATP, levamisole, and ARL67156 prevented vascular calcification and extended longevity by 12% in HGPS mice. "
2.	Mastocytoma 01/01/2015 - "We report that pharmacological inhibition of CD39 in a cultured human mastocytoma cell line (HMC-1) and murine bone marrow-derived MC with ARL67156 (100 µM) increased ATP-induced renin release (≥2-fold), whereas purinergic P2X7 receptors (P2X7R) blockade with A740003 (3 µM) prevented it. "
3.	Abnormal Reflex (Hyperreflexia) 04/15/2015 - "Intravesical perfusion of the ATP diphosphohydrolase apyrase (2 U ml(-1) ), or the ATPase inhibitor ARL67156 (10 μm) increased or decreased reflex bladder activity, respectively. "
4.	Neoplasms (Cancer) 01/01/2022 - "Upon near-infrared irradiation, nanoparticle-produced ROS induced ATP release from MOC1 cancer cells in vitro and triggered the cleavage of phenylboronic ester, facilitating the release of ARL67156 from the nanoparticles. "
5.	Ischemia 08/24/2012 - "Correspondingly, inhibition of ATP breakdown by addition of the selective ecto-ATPase inhibitor ARL67156 significantly reduced ischemia-induced apoptosis. "

Related Drugs and Biologics

1.	Adenosine Triphosphate (ATP)
2.	ectoATPase
3.	Adenosine (Adenocard)
4.	Purinergic P1 Receptor Antagonists
5.	Purinergic P2X7 Receptors
6.	GATA Transcription Factors
7.	Small Interfering RNA (siRNA)
8.	Ethylene Glycol (Monoethylene Glycol)
9.	Purinergic P1 Receptors (Adenosine Receptor)
10.	Cytokines