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17-phenyltrinorprostaglandin E2

an EP1 receptor agonist

Also Known As:

17-Ph-trinor-PGE2; 17-phenyl-omega-trinor PGE2

Networked: 2 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Lipids: 114793
- Fatty Acids: 27405
  - Unsaturated Fatty Acids: 8236
    - Eicosanoids: 3262
      - Prostaglandins: 17100
        Prostaglandins E: 2673
        Dinoprostone: 10047
        17-phenyltrinorprostaglandin E2: 2
Biological Factors: 2472
- Inflammation Mediators: 1113
  - Autacoids: 276
    - Eicosanoids: 3262
      - Prostaglandins: 17100
        Prostaglandins E: 2673
        Dinoprostone: 10047
        17-phenyltrinorprostaglandin E2: 2

Related Diseases

1.	Hyperthermia 08/29/1997 - "In the present study, to determine the sites in the brain where PGE2 induces hyperthermia through EP1 receptors, we microinjected an EP1 receptor agonist, 17-phenyl-omega-trinor PGE2 (17-Ph-PGE2, 100 ng) into different sites in the rat brain and observed the colonic temperature (Tco) for 2 h in a 23 +/- 1 degrees C environment. "
2.	Hyperalgesia 07/01/1994 - "Sulprostone (EP1 < EP3) and 17-phenyl-omega-trinor PGE2 (EP1 > EP3) showed a bell-shaped hyperalgesia at lower doses of 5 pg-5 ng kg-1 and 50 pg-50 ng kg-1, respectively. " 07/01/1994 - "3. 17-Phenyl-omega-trinor PGE2 (EP1 > EP3) and 16,16-dimethyl PGE2 (EP1 = EP2 = EP3) were as potent as PGE2 in inducing allodynia, and more potent than sulprostone. "

Related Drugs and Biologics

1.	Dinoprostone (PGE2)
2.	sulprostone