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FM 4-64

a lipophilic styryl dye; a vital stain for the vacuolar membrane

Also Known As:

FM-4-64; FM4-64; N-(3-triethylammoniumpropyl)-4-(4-diethylaminophenylhexatrienyl)pyridinium dibromide

Networked: 11 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Inorganic Chemicals: 9
- Nitrogen Compounds: 67
  - Ammonium Compounds: 1606
    - Quaternary Ammonium Compounds: 136
      - FM 4-64: 11
Organic Chemicals: 133
- Amines: 4871
  - Quaternary Ammonium Compounds: 136
    - FM 4-64: 11
- Onium Compounds
  - Quaternary Ammonium Compounds: 136
    - FM 4-64: 11
Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyridines: 88
    - Pyridinium Compounds: 5
      - FM 4-64: 11

Experts

1.	Ammanathan, Veena: 1 article (01/2020)
2.	Chavalmane, Aravinda K: 1 article (01/2020)
3.	Jadhav, Vidya: 1 article (01/2020)
4.	Manjithaya, Ravi: 1 article (01/2020)
5.	Mishra, Piyush: 1 article (01/2020)
6.	Muthusamy, Sasikumar: 1 article (01/2020)
7.	Siddamadappa, Chandrashekaran: 1 article (01/2020)
8.	Bizan, Jakub: 1 article (01/2019)
9.	Goto-Yamada, Shino: 1 article (01/2019)
10.	Hara-Nishimura, Ikuko: 1 article (01/2019)

Related Diseases

1.	Starvation 01/01/2019 - "Under sucrose starvation, application of a papain protease inhibitor E-64d to the Arabidopsis root and tobacco BY-2 cells induced the accumulation of vesicles, labeled with a fluorescent membrane marker FM4-64. " 09/10/2004 - "On the other hand, the disorganization of the mitochondrial network induced by rapamycin treatment or 15 h of nitrogen starvation was followed in cells expressing mitochondria-targeted green fluorescent protein; a rapid colocalization of green fluorescent protein fluorescence with vacuole-selective FM4-64 labeling was observed in the wild-type but not in the Deltauth1 strain. "
2.	Infections 12/01/2002 - "FM4-64 was internalized by both ungerminated conidia and conidial germlings on the rice leaf suggesting that endocytosis might play a significant role in spore germination and germ tube growth during the pre-penetration phase of infection." 01/01/2020 - "3-MA: 3-methyladenine; BafA1: bafilomycin A1; CFU: colony-forming units; DQ-BSA: dye quenched-bovine serum albumin; EEA1: early endosome antigen 1; FITC: fluorescein isothiocyanate; FM 4-64: pyridinium,4-(6-[4-{diethylamino}phenyl]-1,3,5-hexatrienyl)-1-(3[triethylammonio] propyl)-dibromide; GFP: green fluorescent protein; LAMP1: lysosomal associated membrane protein 1; MAPILC3/LC3: microtubule associated protein 1 light chain 3; MOI: multiplicity of infection; MTOR: mechanistic target of rapamycin kinase; RFP: red fluorescent protein; SCVs: Salmonella-containing vacuoles; SD: standard deviation; SDS: sodium dodecyl sulfate; SEM: standard mean error; SQSTM1: sequestosome 1; TBK1: TANK binding kinase 1; TFEB: transcription factor EB."
3.	Hypersensitivity (Allergy) 06/01/2017 - "This, along with normal post-late endosome trafficking of the vital dye FM4-64, establishes that severe hypersensitivity to hygromycin B correlates specifically with compromised trans-Golgi and late endosome interface. " 01/01/2008 - "Absence of DRP1A reduces endocytotic uptake of FM4-64 into the cytoplasm of root cells and the hypersensitivity of elongation and radial swelling in rsw9 to the trafficking inhibitor monensin suggests that impaired endocytosis may contribute to the development of shorter fatter roots, probably by reducing cellulose synthesis."
4.	Phototoxic Dermatitis (Phototoxicity) 03/28/2015 - "The doubly-charged dyes showed phototoxicity at concentrations greater than 10 μM, although they do not generate singlet oxygen, indicating that the phototoxicity is type I rather than type II. The doubly-charged thiophene dyes are more effective than FM4-64 as SHG dyes for live cells."
5.	Pain (Aches) 01/01/2012 - "Intradermal injection of NTX in the area of IoNC alleviated IoNC-induced pain behavior and reduced the exaggerated FM4-64 release in trigeminal ganglion neurons."

Related Drugs and Biologics

1.	Coloring Agents (Dyes)
2.	Green Fluorescent Proteins
3.	Sirolimus (Rapamycin)
4.	Lysosomal-Associated Membrane Protein 1
5.	Singlet Oxygen
6.	Fluorescein (Funduscein)
7.	Fluorescein-5-isothiocyanate (FITC)
8.	Transcription Factors (Transcription Factor)
9.	Thiophenes
10.	Sucrose (Saccharose)

Related Therapies and Procedures

1.	Intradermal Injections