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1- (2- (tris(4- methoxyphenyl)methoxy)ethyl)- 3- piperidinecarboxylic acid

selective inhibitor of GABA transporter 3 (GAT-3); structure in first source

Also Known As:

SNAP 5114; SNAP-5114

Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Iwai, Takashi: 1 article (01/2022)
2.	Oyama, Misa: 1 article (01/2022)
3.	Tanabe, Mitsuo: 1 article (01/2022)
4.	Watanabe, Shun: 1 article (01/2022)
5.	Chang, Lei: 1 article (01/2018)
6.	Dong, Jian: 1 article (01/2018)
7.	Li, Fei: 1 article (01/2018)
8.	Liang, Hai-Ying: 1 article (01/2018)
9.	Lin, Yu-Hui: 1 article (01/2018)
10.	Luo, Chun-Xia: 1 article (01/2018)

Related Diseases

1.	Pain (Aches) 04/01/2010 - "To these aims, we first analyzed the pain behaviors following the spinal administration of GABA antagonists (1 microg bicuculline/rat and 5 microg phaclofen/rat), agonists (1 microg muscimol/rat and 0.5 microg baclofen/rat) or GABA transporter (GAT) inhibitors (20 microg NNC-711/rat and 1 microg SNAP-5114/rat) into naïve or neuropathic animals. "
2.	Infarction (Infarctions) 01/01/2018 - "The GAT-3/4-selective antagonist SNAP-5114 reduced tonic inhibition and promoted function recovery, suggesting that increased tonic inhibition in the peri-infarct cortex was due to GABA release from reversed GAT-3/4 in reactive astrocytes. "
3.	Hypersensitivity (Allergy) 01/01/2022 - "Consistently, the analgesic effect of intrathecally injected NNC-711 and SNAP-5114 in mice developing mechanical hypersensitivity after partial sciatic nerve ligation was abolished by CGP55845. "

Related Drugs and Biologics

1.	NNC 711 (NO 711)
2.	GAT
3.	GABA Plasma Membrane Transport Proteins
4.	GABA Antagonists
5.	Muscimol
6.	gamma-Aminobutyric Acid (GABA)
7.	Bicuculline
8.	Baclofen
9.	Analgesics (Analgesic Drugs)
10.	phaclofen

Related Therapies and Procedures

1.	Ligation