phenserine

a carbamate analog of physostigmine; a long-acting inhibitor of cholinesterase

Also Known As:

N-phenylcarbamoyl eseroline; N-phenylcarbamoyleseroline; posiphen; pyrrolo(2,3-b)indol-5-ol, 1,2,3,3a,8,8a-hexahydro-1,3a,8-trimethyl-, 5-(N-phenylcarbamate), (3aS,8aR)-

Networked: 45 relevant articles (3 outcomes, 8 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Greig, Nigel H: 18 articles (02/2020 - 12/2004)
2.	Becker, Robert E: 7 articles (01/2020 - 01/2010)
3.	Lahiri, Debomoy K: 6 articles (01/2018 - 12/2004)
4.	Hoffer, Barry J: 5 articles (01/2020 - 01/2016)
5.	Chiang, Yung-Hsiao: 4 articles (01/2020 - 09/2017)
6.	Luo, Yu: 4 articles (01/2018 - 01/2013)
7.	Sambamurti, Kumar: 4 articles (01/2018 - 07/2005)
8.	Holloway, Harold W: 4 articles (01/2016 - 01/2007)
9.	Yu, Qian-Sheng: 4 articles (01/2016 - 04/2007)
10.	Greig, N H: 4 articles (09/2007 - 01/2000)

Related Diseases

1.	Alzheimer Disease (Alzheimer's Disease) 09/01/2012 - "These results confirm preclinical POM studies, demonstrate that pharmacologically relevant drug/metabolite levels reach brain and support the continued clinical optimisation and evaluation of Posiphen for MCI and Alzheimer's disease." 11/20/2023 - "An initial application to screening the effects of an Alzheimer's disease drug candidate, Posiphen, using fluorescence cell sorting is presented. " 01/01/2018 - "(-)-Phenserine and Inhibiting Pre-Programmed Cell Death: In Pursuit of a Novel Intervention for Alzheimer's Disease." 09/09/2017 - "The second is (-)-phenserine ((-)-Phen) that was originally developed as an experimental Alzheimer's disease (AD) drug. " 01/01/2016 - "Molecular pathways associated with lipid peroxidation were found to be regulated by mTBI, and treatment of mTBI animals with phenserine effectively reversed injury-induced regulations in the 'Blalock Alzheimer's Disease Up' pathway. "
2.	Traumatic Brain Injuries (Traumatic Brain Injury) 01/01/2020 - "(-)-Phenserine tartrate (PhenT) as a treatment for traumatic brain injury." 09/09/2017 - "Repositioning drugs for traumatic brain injury - N-acetyl cysteine and Phenserine." 09/01/2019 - "(-)-Phenserine Ameliorates Contusion Volume, Neuroinflammation, and Behavioral Impairments Induced by Traumatic Brain Injury in Mice."
3.	Infarction (Infarctions) 12/15/2017 - "In MCAO challenged rats, (-)-phenserine reduced infarction volume, cell death and improved body asymmetry, a behavioral measure of stoke impact. " 02/21/2020 - "Early post-treatment with Posiphen reduced ER stress signals, IBA1 immunoreactivity, TUNEL and infarction in the ischemic cortex, as well as neurological deficits in stroke rats. "
4.	Neuroinflammatory Diseases 10/01/2019 - "Herein, we evaluated the effect on pre-programmed cell death/neuroinflammation/synaptic integrity and function of (-)-Phenserine tartrate (Phen), an agent originally developed for AD. " 09/01/2019 - "(-)-Phenserine Ameliorates Contusion Volume, Neuroinflammation, and Behavioral Impairments Induced by Traumatic Brain Injury in Mice." 10/01/2019 - "(-)-Phenserine and the prevention of pre-programmed cell death and neuroinflammation in mild traumatic brain injury and Alzheimer's disease challenged mice."
5.	Contusions 09/01/2019 - "(-)-Phenserine Ameliorates Contusion Volume, Neuroinflammation, and Behavioral Impairments Induced by Traumatic Brain Injury in Mice."

Related Drugs and Biologics

1.	Amyloid (Amyloid Fibrils)
2.	Cholinesterase Inhibitors (Anticholinesterases)
3.	Proteins (Proteins, Gene)
4.	tartaric acid (tartrate)
5.	Physostigmine
6.	Acetylcholinesterase
7.	Glucose (Dextrose)
8.	Butyrylcholinesterase
9.	Caspase 3 (Caspase-3)
10.	Therapeutic Uses

Related Therapies and Procedures

1.	Therapeutics
2.	Stents
3.	Drug Therapy (Chemotherapy)
4.	Oral Administration