2-aminoethylamide N- ((2- (hydroxyaminocarbonyl)methyl)- 4- methylpentanoyl)- 3- (2'- naphthyl)alanylalanine

Also Known As:

N-((2-(hydroxyaminocarbonyl)methyl)-4-methylpentanoyl)-3-(2'-naphthyl)alanylalanine, 2-aminoethylamide; TAPI (inhibitor); TAPI-1

Networked: 6 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Peptides: 82426
  - Oligopeptides: 519
    - Dipeptides: 945
      - 2-aminoethylamide N-((2-(hydroxyaminocarbonyl)methyl)-4-methylpentanoyl)-3-(2'-naphthyl)alanylalanine: 6
Organic Chemicals: 133
- Amines: 4871
  - Hydroxylamines: 16
    - Hydroxamic Acids: 239
      - 2-aminoethylamide N-((2-(hydroxyaminocarbonyl)methyl)-4-methylpentanoyl)-3-(2'-naphthyl)alanylalanine: 6
- Carboxylic Acids: 973
  - Hydroxy Acids: 94
    - Hydroxamic Acids: 239
      - 2-aminoethylamide N-((2-(hydroxyaminocarbonyl)methyl)-4-methylpentanoyl)-3-(2'-naphthyl)alanylalanine: 6

Experts

1.	Bishayi, Biswadev: 1 article (01/2020)
2.	Sultana, Sahin: 1 article (01/2020)
3.	Chang, Deh-Ming: 1 article (02/2014)
4.	Liu, Fei-Lan: 1 article (02/2014)
5.	Wu, Cheng-Chi: 1 article (02/2014)
6.	Katayama, Ichiro: 1 article (01/2010)
7.	Kitaba, Shun: 1 article (01/2010)
8.	Murota, Hiroyuki: 1 article (01/2010)
9.	Terao, Mika: 1 article (01/2010)
10.	Abraham, Wickliffe C: 1 article (08/2008)

Related Diseases

1.	Necrosis 12/01/2005 - "Finally, HAT-induced AR release was eliminated by blockade of tumour necrosis factor alpha-converting enzyme (TACE) by the TAPI-1 and RNA interference, suggesting that TACE activity is necessary for HAT-induced AR release. "
2.	Arthritis (Polyarthritis) 01/01/2020 - "Throughout the experiment, the severity of arthritis was obtained to be significantly low after TAPI-1 administration. " 01/01/2020 - "Arthritis index and histopathology confirmed effectiveness of TAPI-1 in mitigating inflammation induced paw swelling and less bone-cartilage destruction in the arthritic knee joints. " 01/01/2020 - "This study aimed to unveil the potential anti-arthritic effects of TAPI-1 (TNF-α processing inhibitor-1), an inhibitor that inhibits TACE (TNF-α converting enzyme) mediated release of soluble TNF-α and its receptors along with attenuation of other inflammatory and joint destructive factors responsible for the progression of arthritis. "
3.	Tetanus 08/01/2008 - "Pharmacological inhibition of alpha-secretase and other a-disintegrin-and-metalloproteases by TAPI-1 reduced both LTP and tetanus-evoked NMDA receptor-mediated currents in dentate granule cells. "
4.	Neoplasms (Cancer) 11/26/2023 - "TAPI-1 Exhibits Anti-tumor Efficacy in Human Esophageal Squamous Cell Carcinoma Cells via Suppression of NF-κB Signaling Pathway."
5.	Inflammation (Inflammations) 01/01/2020 - "Arthritis index and histopathology confirmed effectiveness of TAPI-1 in mitigating inflammation induced paw swelling and less bone-cartilage destruction in the arthritic knee joints. "

Related Drugs and Biologics

1.	Enzymes
2.	Amyloid Precursor Protein Secretases (beta-Secretase)
3.	Osteopontin
4.	RANK Ligand
5.	Metalloproteases (Metalloproteinases)
6.	Small Interfering RNA (siRNA)
7.	Matrix Metalloproteinase 2 (Gelatinase A)
8.	Disintegrins
9.	N-Methyl-D-Aspartate Receptors (NMDA Receptors)

Related Therapies and Procedures

1.	Injections