cardiotrophin 1

a cytokine that induces cardiac myocyte hypertrophy; member of the leukemia inhibitory factor/ciliary neurotrophic factor/oncostatin M/interleukin 6/interleukin 11 family of cytokines; MW 21.5 kDa; amino acid sequence given in first source; GenBank U18366

Networked: 23 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Díez, Javier: 3 articles (03/2014 - 08/2012)
2.	Lacolley, Patrick: 3 articles (01/2013 - 06/2010)
3.	Rossignol, Patrick: 3 articles (01/2013 - 06/2010)
4.	Zannad, Faiez: 3 articles (01/2013 - 06/2010)
5.	Calvier, Laurent: 2 articles (01/2013 - 08/2012)
6.	Labat, Carlos: 2 articles (01/2013 - 08/2012)
7.	López-Andrés, Natalia: 2 articles (01/2013 - 08/2012)
8.	Akkiz, Hikmet: 1 article (06/2022)
9.	Akkoc, Yunus: 1 article (06/2022)
10.	Arikan, Soykan: 1 article (06/2022)

Related Diseases

1.	Status Epilepticus (Complex Partial Status Epilepticus) 11/01/2011 - "In this study, we studied the effects of hippocampal transplantation of neural stem cells (NSCs) overexpressing cardiotrophin 1 (CT1) on hippocampal mossy fiber sprouting (MFS) in a rat model of status epilepticus (SE). "
2.	Hypertrophy 04/01/1998 - "[Cardiotrophin-1: a new cytokin that induces cardiac myocyte hypertrophy]." 02/14/1995 - "Expression cloning of cardiotrophin 1, a cytokine that induces cardiac myocyte hypertrophy." 02/14/1995 - "Several members of this family that are known to signal through the transmembrane protein gp130 stimulate cardiac myocyte hypertrophy, like cardiotrophin 1, suggesting that the gp130 signaling pathway may play a role in cardiac hypertrophy. " 10/01/2017 - "We identify the cytokine cardiotrophin 1 (CT1) as a factor capable of recapitulating the key features of physiologic growth of the heart including transient and reversible hypertrophy of the myocardium, and stimulation of cardiomyocyte-derived angiogenic signals leading to increased vascularity. " 02/14/1995 - "Reasoning that fetal or embryonic growth factors may mediate the onset of cardiac hypertrophy, we have coupled expression cloning with an embryonic stem cell-based model of cardiogenesis to isolate a 21.5-kDa protein, cardiotrophin 1, that potently induces cardiac myocyte hypertrophy in vitro. "
3.	Cardiomegaly (Heart Hypertrophy) 04/01/2013 - "Cardiotrophin 1 (CT-1) is a recently described cytokine originally isolated from the heart where it has been shown to play an important role in apoptotic protection of cardiomyocytes and heart hypertrophy. " 02/14/1995 - "Several members of this family that are known to signal through the transmembrane protein gp130 stimulate cardiac myocyte hypertrophy, like cardiotrophin 1, suggesting that the gp130 signaling pathway may play a role in cardiac hypertrophy. " 05/01/2014 - "Cardiotrophin 1 (CT-1) is an interleukin 6-related cytokine recently implicated in cardiac hypertrophy and vascular damage in essential hypertension (EH). " 02/14/1995 - "Reasoning that fetal or embryonic growth factors may mediate the onset of cardiac hypertrophy, we have coupled expression cloning with an embryonic stem cell-based model of cardiogenesis to isolate a 21.5-kDa protein, cardiotrophin 1, that potently induces cardiac myocyte hypertrophy in vitro. "
4.	Fibrosis (Cirrhosis) 01/01/2019 - "In a later stage, obstructed kidneys from cardiotrophin-1-/- mice show higher fibrosis than obstructed kidneys from wild-type mice. " 08/01/2012 - "Cardiotrophin 1 is involved in cardiac, vascular, and renal fibrosis and dysfunction." 01/01/2013 - "Cardiotrophin 1 (CT-1), an interleukin 6 family member, promotes fibrosis and arterial stiffness. "
5.	Neoplasms (Cancer) 01/01/2023 - "Tumor-derived CTF1 (cardiotrophin 1) is a critical mediator of stroma-assisted and autophagy-dependent breast cancer cell migration, invasion and metastasis." 01/01/2023 - ": ACTA2/α-SMA: actin, alpha 2, smooth muscle CAFs: cancer- or carcinoma-associated fibroblasts CNT Ab.: control antibody CNTF: ciliary neurotrophic factor CTF1: cardiotrophin 1 CTF1 Neut. " 11/01/2023 - "Many cytokines from the IL-6 family, which includes IL-6, oncostatin M, leukemia inhibitory factor, IL-11, IL-27, IL-31, ciliary neurotrophic factor, cardiotrophin 1, and cardiotrophin-like cytokine factor 1, have been shown to elicit tumor-promoting roles by modulating the TME, making them attractive therapeutic targets for cancer treatment.The"

Related Drugs and Biologics

1.	Cytokines
2.	Interleukin-6 (Interleukin 6)
3.	Ciliary Neurotrophic Factor (CNTF)
4.	Leukemia Inhibitory Factor
5.	Interleukin-27 (Interleukin 27)
6.	Oncostatin M
7.	Fatty Acid-Binding Proteins
8.	Intercellular Signaling Peptides and Proteins (Growth Factors)
9.	Collagen Type I (Type I Collagen)
10.	Brain Natriuretic Peptide (Natrecor)

Related Therapies and Procedures

1.	Transplantation
2.	Electric Countershock (Cardioversion)