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FD 895

from the fermentation broth of Streptomyces hygroscopicus; structure given in first source

Also Known As:

FD-895

Networked: 2 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Lactones: 1549
  - Macrolides: 4391
    - FD 895: 2
  - Polyketides: 231
    - Macrolides: 4391
      - FD 895: 2
Polycyclic Compounds: 6
- Macrocyclic Compounds: 15
  - Polyketides: 231
    - Macrolides: 4391
      - FD 895: 2

Experts

1.	Burkart, Michael D: 2 articles (01/2022 - 07/2015)
2.	Castro, Januario E: 2 articles (01/2022 - 07/2015)
3.	Kashyap, Manoj K: 2 articles (01/2022 - 07/2015)
4.	Kipps, Thomas J: 2 articles (01/2022 - 07/2015)
5.	Kumar, Deepak: 2 articles (01/2022 - 07/2015)
6.	La Clair, James J: 2 articles (01/2022 - 07/2015)
7.	Villa, Reymundo: 2 articles (01/2022 - 07/2015)
8.	Spaanderman, Ide: 1 article (01/2022)
9.	Yu, Zhe: 1 article (01/2022)
10.	Benner, Chris: 1 article (07/2015)

Related Diseases

1.	B-Cell Chronic Lymphocytic Leukemia (Chronic Lymphocytic Leukemia) 07/01/2015 - "Targeting the spliceosome in chronic lymphocytic leukemia with the macrolides FD-895 and pladienolide-B." 07/01/2015 - "We report studies using FD-895 and pladienolide-B in primary leukemia cells derived from patients with chronic lymphocytic leukemia and leukemia-lymphoma cell lines. "
2.	Lymphoma (Lymphomas) 07/01/2015 - "We report studies using FD-895 and pladienolide-B in primary leukemia cells derived from patients with chronic lymphocytic leukemia and leukemia-lymphoma cell lines. "
3.	Leukemia 07/01/2015 - "We report studies using FD-895 and pladienolide-B in primary leukemia cells derived from patients with chronic lymphocytic leukemia and leukemia-lymphoma cell lines. "
4.	Neoplasms (Cancer) 01/01/2022 - "The RNA splicing modulators such as FD-895 and pladienolide B have been investigated in different malignancies to target/modulate spliceosome for therapeutic purpose. " 01/01/2022 - "We show that FD-895 and pladienolide B induces higher apoptosis levels than conventional chemotherapy in different solid tumors. " 01/01/2022 - "These results indicate FD-895 and pladienolide B inhibit Wnt signaling by decreasing LRP6 phosphorylation and modulating mRNA splicing through induction of intron retention in solid tumors."

Related Drugs and Biologics

1.	pladienolide B
2.	Macrolides
3.	Messenger RNA (mRNA)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)