FR 901451

a leukocyte elastase inhibitor from the fermentation broth of Flexibacter; may be useful for treatment of destructive lung diseases, such as pulmonary emphysema; structure given in first source

Also Known As:

FR-901451; FR901451

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Polycyclic Compounds: 6
- Macrocyclic Compounds: 15
  - Cyclic Peptides: 530
    - FR 901451: 1
Amino Acids, Peptides, and Proteins: 1
- Peptides: 82426
  - Cyclic Peptides: 530
    - FR 901451: 1

Related Diseases

1.	Pulmonary Emphysema 12/01/1994 - "These results suggest that FR901451 could be clinically useful agent for the treatment of the destructive lung disease such as pulmonary emphysema."
2.	Lung Diseases (Lung Disease) 12/01/1994 - "These results suggest that FR901451 could be clinically useful agent for the treatment of the destructive lung disease such as pulmonary emphysema."
3.	Hemorrhage 12/01/1994 - "Intratracheal (i.t.) or intravenous (i.v.) administration of FR901451, a potent inhibitor of human leukocyte elastase (HLE) prevented HLE-induced lung hemorrhage in hamsters with ED50 values of 10.5 micrograms/site and 8.1 mg/kg, respectively. "

Related Drugs and Biologics

1.	Leukocyte Elastase (Neutrophil Elastase)