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Bio-Agent Context: Research Results
Organic Chemicals: 58
Carboxylic Acids: 83
Hydroxy Acids: 24
4-hydroxy-2-nonenoic acid: 1
Hepatocellular Carcinoma (Hepatoma)
01/01/1999 - "
The oxidative metabolite of 4-HNE, 4-hydroxy-2-nonenoic acid (HNA), produced by ALDH, appeared rapidly in the intracellular fraction achieving concentrations of 0.28 HNA nmol 10(6) hepatoma cells-1 and was efficiently eliminated with a first-order rate constant of 0.988 min-1.
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