BCL2-associated athanogene 1 protein

binds Hsp70 and Hsc70; BAG-1M and BAG-1L also bind steroid receptors; binds to Bcl-2 protein and has anti-cell death activity; RefSeq NM_004323 (human); NM_009736 (mouse); XM_216377 (rat)

Also Known As:

BAG-1 long protein; BAG-1 protein; BAG-1 protein, human; BAG-1L protein; BAG-1M protein; BAG1 protein, human; BCL2-associated athanogene 1 protein, human; BCL2-associated athanogene protein, human; Bag-1 protein, rat; Bag1 protein, mouse; Bag1 protein, rat; Bcl2-associated athanogene 1 protein, rat; Bcl2-associated athanogene 1, mouse; HAP46 protein, human; Hap46 protein; Hap46 protein, mouse; Hap50 protein; RAP46 protein; nuclear receptor-associated protein, 46-kDa

Networked: 25 relevant articles (1 outcomes, 2 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Transcription Factors: 38804
    - BCL2-associated athanogene 1 protein: 25
  - DNA-Binding Proteins: 2009
    - BCL2-associated athanogene 1 protein: 25

Experts

1.	Hague, A: 2 articles (10/2012 - 03/2005)
2.	Paraskeva, C: 2 articles (10/2012 - 03/2005)
3.	Williams, A C: 2 articles (10/2012 - 03/2005)
4.	Chen, Jun: 2 articles (01/2012 - 06/2008)
5.	Tang, Shou-Ching: 2 articles (01/2012 - 04/2004)
6.	Zhou, Qinghua: 2 articles (01/2012 - 10/2009)
7.	Reed, John C: 2 articles (06/2006 - 01/2004)
8.	Krajewski, S: 2 articles (02/2001 - 04/2000)
9.	Reed, J C: 2 articles (02/2001 - 04/2000)
10.	Takayama, S: 2 articles (02/2001 - 04/2000)

Related Diseases

1.	Breast Neoplasms (Breast Cancer) 02/15/2001 - "We performed a retrospective correlative analysis of BAG-1 protein expression in breast tumors derived from a cohort of early-stage breast cancer patients. " 04/01/2004 - "BAG-1 protein species are localized differentially; nuclear expression may be associated with a shorter disease-free and overall survival in early stage breast cancer, while cytoplasmic expression has been associated with longer survival in non-small cell lung cancer. " 11/01/2023 - "Following this, we performed exploratory immunohistochemistry to determine BAG-1L protein expression in normal human, matched castration-sensitive prostate cancer (CSPC) and castration-resistant prostate cancer (CRPC), unmatched primary and metastatic CRPC, and early breast cancer tissues. "
2.	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 10/20/2009 - "The expression level of bag-1 protein is closely related to the differentiation degree of non-small cell lung cancer. " 04/01/2004 - "BAG-1 protein species are localized differentially; nuclear expression may be associated with a shorter disease-free and overall survival in early stage breast cancer, while cytoplasmic expression has been associated with longer survival in non-small cell lung cancer. " 10/20/2009 - "bcl-2 protein expression was highly positive correlated with the bag-1 protein expression in non-small cell lung cancer (r =0.371, P<0.01), and bcl-2 protein was highly negative correlated with bax protein expression (r=-0.225, P<0.01). "
3.	Colorectal Neoplasms (Colorectal Cancer) 11/04/2002 - "The aim of our study was to investigate the immunohistochemical staining pattern of BAG-1 protein in patients with colorectal cancer and examine associations of BAG-1 expression with various clinicopathological factors and patient survival. " 11/04/2019 - "The anti-apoptotic BAG-1 protein isoforms are known to be overexpressed in colorectal tumors and are considered to be potential therapeutic targets. "
4.	Prostatic Neoplasms (Prostate Cancer) 11/01/2023 - "Development and Validation of a New BAG-1L-Specific Antibody to Quantify BAG-1L Protein Expression in Advanced Prostate Cancer." 06/01/2006 - "Expression of BAG-1 protein correlates with aggressive behavior of prostate cancers." 11/01/2023 - "Following this, we performed exploratory immunohistochemistry to determine BAG-1L protein expression in normal human, matched castration-sensitive prostate cancer (CSPC) and castration-resistant prostate cancer (CRPC), unmatched primary and metastatic CRPC, and early breast cancer tissues. " 11/01/2023 - "Studies investigating the clinical importance of BAG-1L protein expression in advanced prostate cancer have been limited by the paucity of antibodies that specifically recognize the long isoform. "
5.	Neoplasms (Cancer) 01/01/2022 - "Bag-1 protein is a crucial target in cancer to increase the survival and proliferation of cells. " 06/20/2008 - "[Expression and functions of BAG-1 protein in human cancer cells.]." 06/01/2008 - "Our data indicated that BAG-1 protein was deregulated in this disease similar to some other malignancies such as breast and colon cancer. " 01/01/2004 - "All breast cancers expressed BAG-1 protein, and, in individual tumors, 40-100% of neoplastic cells stained positive for this protein. " 08/27/1998 - "Human BAG-1/RAP46 protein is generated as four isoforms by alternative translation initiation and overexpressed in cancer cells."

Related Drugs and Biologics

1.	Protein Isoforms (Isoforms)
2.	Antibodies
3.	Proteins (Proteins, Gene)
4.	bcl-2-Associated X Protein (bcl 2 Associated X Protein)
5.	Retinoids
6.	Paraffin
7.	Cisplatin (Platino)
8.	abiraterone

Related Therapies and Procedures

1.	Castration
2.	Prostatectomy (Retropubic Prostatectomy)