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thiazopyr
structure in first source
Networked:
2
relevant articles (
0
outcomes,
1
trials/studies)
Bio-Agent Context: Research Results
Heterocyclic Compounds: 198
1-Ring Heterocyclic Compounds
Azoles: 2138
Thiazoles: 392
thiazopyr: 2
Pyridines: 88
Nicotinic Acids: 13
Niacin: 3030
thiazopyr: 2
Heterocyclic Acids
Nicotinic Acids: 13
Niacin: 3030
thiazopyr: 2
Organic Chemicals: 133
Sulfur Compounds: 278
Thiazoles: 392
thiazopyr: 2
Experts
1.
Berry, Sir Colin
: 1 article (11/2006)
2.
Boobis, Alan R
: 1 article (11/2006)
3.
Cohen, Samuel M
: 1 article (11/2006)
4.
Dellarco, Vicki L
: 1 article (11/2006)
5.
McGregor, Douglas
: 1 article (11/2006)
Related Diseases
1.
Neoplasms (Cancer)
01/01/1997 - "
In the studies reported here we have evaluated the mechanism of thiazopyr-induced thyroid tumors by studying the effect of thiazopyr on a number of endpoints that indicate hypothalamic-pituitary-thyroid homeostasis.
"
11/01/2006 - "
Thiazopyr increases the incidence of male rat thyroid follicular-cell tumors; however, it is not carcinogenic in mice.
"
11/01/2006 - "
Thiazopyr and thyroid disruption: case study within the context of the 2006 IPCS Human Relevance Framework for analysis of a cancer mode of action.
"
01/01/1997 - "
In summary, evidence is presented for a hormonally mediated, threshold-dependent process for the development of thyroid follicular cell tumors from high-dose thiazopyr administration in male rats.
"
01/01/1997 - "
Chronic administration of thiazopyr in the diet at dose levels of 1000 and 3000 ppm, but not 100 ppm, has demonstrated an increase in thyroid follicular cell tumors in male Sprague-Dawley rats.
"
2.
Hypertrophy
01/01/1997 - "
Increased levels of serum TSH, T3, and rT3, decreased levels of T4, and an increased incidence of thyroid follicular cell hypertrophy and hyperplasia were observed 56 days after the initiation of 3000 ppm thiazopyr.
"
01/01/1997 - "
The sustained increase in TSH by thiazopyr appears responsible for the stimulation of the thyroid follicular cells resulting in follicular cell hypertrophy, hyperplasia, and ultimately neoplasia.
"
3.
Hyperplasia
01/01/1997 - "
Increased levels of serum TSH, T3, and rT3, decreased levels of T4, and an increased incidence of thyroid follicular cell hypertrophy and hyperplasia were observed 56 days after the initiation of 3000 ppm thiazopyr.
"
01/01/1997 - "
The sustained increase in TSH by thiazopyr appears responsible for the stimulation of the thyroid follicular cells resulting in follicular cell hypertrophy, hyperplasia, and ultimately neoplasia.
"
Related Drugs and Biologics
1.
Thyroid Hormones