major vault protein

from vertebrates; MW about 100 kDa; GenBank U09870

Also Known As:

Lrp lung resistance protein; MVP protein, human; MVP protein, rat; MVP protein, zebrafish; Mvp protein, mouse; lung resistance protein; major vault protein p110; major vault protein, human; major vault protein, mouse; major vault protein, rat; p110 major vault protein

Networked: 234 relevant articles (3 outcomes, 33 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Carrier Proteins: 12999
    - RNA-Binding Proteins: 3262
      - Ribonucleoproteins: 1286
        Vault Ribonucleoprotein Particles: 1
        major vault protein: 234
  - Nucleoproteins: 1870
    - RNA-Binding Proteins: 3262
      - Ribonucleoproteins: 1286
        Vault Ribonucleoprotein Particles: 1
        major vault protein: 234

Experts

1.	Wiemer, Erik A C: 11 articles (01/2022 - 12/2002)
2.	Scheper, Rik J: 6 articles (07/2004 - 12/2002)
3.	Scheffer, George L: 6 articles (05/2004 - 12/2002)
4.	Furukawa, Tatsuhiko: 5 articles (01/2014 - 03/2006)
5.	Ben, Jingjing: 4 articles (01/2022 - 01/2019)
6.	Chen, Qi: 4 articles (01/2022 - 01/2019)
7.	Ma, Junqing: 4 articles (01/2022 - 01/2019)
8.	Qi, Yu: 4 articles (01/2022 - 01/2019)
9.	Ikeda, Ryuji: 4 articles (01/2014 - 10/2008)
10.	Takeda, Yasuo: 4 articles (01/2014 - 10/2008)

Related Diseases

1.	Neoplasms (Cancer) 08/06/2009 - "The aim of the present study was to assess the relation of Major Vault Protein expression and tumor hypoxia in clinical cervical tumors. " 04/01/2009 - "Recent studies have shown that major vault protein (MVP) is involved in intracellular signaling, cell survival, differentiation and innate immunity and that it is not directly responsible for nucleo-cytoplasmic drug transport in multi-drug-resistant cancer cell lines. " 01/01/2022 - "In cancer, major vault protein (MVP) is thought to contribute to drug resistance. " 01/01/2020 - "Augmented dox efflux induced by lung resistance protein (LRP) over expression has been related to multi drug resistance phenotype in various cancers. " 09/10/2013 - "The human major vault protein (MVP) has been implicated in the development of drug resistance in cancer cells. "
2.	Breast Neoplasms (Breast Cancer) 11/01/1999 - "To determine the clinical significance of the lung resistance protein (LRP) in breast cancer, we have studied its expression in primary breast carcinomas (n = 99) and assessed the association of this expression with clinical parameters of the patients. " 11/01/1999 - "Expression of the lung resistance protein (LRP) in primary breast cancer." 10/28/2012 - "Meanwhile, we found that major vault protein (MVP) may be also involved in drug resistance of human breast cancer MCF-7/ADR cells by transporting doxorubicin (DOX) from the action target (i.e. " 11/18/2010 - "In vitro modulation of P-gp activity by zosuquidar and expression of P-gp, multidrug resistance-related protein 1, lung resistance protein, and breast cancer resistance protein, were comparable in the 2 arms. " 05/01/2004 - "CD56 expression, Pgp expression and function, and expression of the additional MDR proteins multidrug resistance protein-1 (MRP-1), lung resistance protein (LRP) and breast cancer resistance protein (BCRP) were studied in pretreatment blasts from 25 CBF-AML patients. "
3.	Carcinoma (Carcinomatosis) 06/01/2000 - "Expression of lung resistance protein in patients with gastric carcinoma and its clinical significance." 03/15/2009 - "Major vault protein may affect nonhomologous end-joining repair and apoptosis through Ku70/80 and bax downregulation in cervical carcinoma tumors." 01/01/2000 - "Loss of function of the tumor suppressor gene p53, increased expression of glutathione-S-transferase pi (GST7pi) and the major vault protein are involved in drug resistance of ovarian carcinomas. " 05/01/1999 - "To investigate the expression and clinical significance of multidrug resistance-associated protein(MRP) and lung resistance protein(LRP) in rectal carcinoma. " 05/01/1999 - "[Expression of multidrug resistance-associated protein (MRP) and lung resistance protein (LRP) in human rectal carcinomas and its clinical significance]."
4.	Leukemia 01/01/2000 - "To investigate the relationship between the expression of lung resistance protein (LRP) gene and drug resistance in patients with acute leukemias (AL). " 01/01/2000 - "[The clinical significance of lung resistance protein (LRP) gene expression in patients with acute leukemia]." 04/01/1996 - "Overexpression of the lung-resistance protein (LRP) in AML has also been linked to advanced age, secondary leukemia, and Pgp overexpression. " 12/01/2006 - "Expression dynamics of drug resistance genes, multidrug resistance 1 (MDR1) and lung resistance protein (LRP) during the evolution of overt leukemia in myelodysplastic syndromes." 08/01/2005 - "Previous studies revealed that lung resistance protein (LRP) and multidrug resistance-associated protein (MRP) relate to drug resistance of childhood leukemia, which is not caused by only one mechanism. "
5.	Lung Neoplasms (Lung Cancer) 12/20/2000 - "To study the relationship between lung resistance protein gene (LRP) expression and clinical pathophysiological characteristics of lung cancer. " 05/15/2019 - "Major vault protein suppresses lung cancer cell proliferation by inhibiting STAT3 signaling pathway." 12/20/2000 - "[Relationship between expression of lung resistance protein gene and clinical pathophysiological characteristics of lung cancer]." 08/01/1996 - "Expression of the human major vault protein LRP in human lung cancer samples and normal lung tissues." 01/01/2019 - "Major vault protein (MVP), as a gene associated with lung multidrug resistance, is associated with multiple chemotherapy resistances of lung cancer. "

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	Member 1 Subfamily B ATP Binding Cassette Transporter
3.	multidrug resistance-associated protein 1
4.	Multidrug Resistance-Associated Proteins
5.	Messenger RNA (mRNA)
6.	Glutathione S-Transferase pi
7.	Metallothionein
8.	2-methoxyisobutylisonitrile (RP 30)
9.	Retinoblastoma Protein
10.	homoserine lactone

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Induction Chemotherapy
3.	Consolidation Chemotherapy
4.	Neoadjuvant Therapy
5.	Therapeutics