|1.||Tanaka, Tetsuji: 11 articles (07/2012 - 01/2004)|
|2.||Yukawa, Kazunori: 11 articles (07/2012 - 01/2004)|
|3.||Chen, Ruey-Hwa: 10 articles (02/2014 - 02/2006)|
|4.||Bai, Tao: 10 articles (07/2012 - 01/2004)|
|5.||Schneider-Stock, Regine: 9 articles (11/2015 - 06/2005)|
|6.||Kimchi, Adi: 7 articles (03/2012 - 04/2004)|
|7.||Kimchi, A: 6 articles (05/2012 - 01/2001)|
|8.||Belinsky, Steven A: 6 articles (12/2009 - 04/2002)|
|9.||Nakamura, Masakatsu: 5 articles (04/2011 - 07/2009)|
|10.||Yamashita, Hiromi: 5 articles (04/2011 - 07/2009)|
05/01/2004 - "Overall (64 months) and disease-free (63 months) survival in the high DAP-kinase expression group were significantly longer compared with the women whose tumors showed a loss of DAP-kinase expression (51 and 43 months, respectively). "
05/01/2008 - "This study was aimed at investigating the death-associated protein kinase (DAPK) promoter methylation and its clinical relevance in cervical cancer. "
07/24/1997 - "In this study the expression of DAP-kinase was examined in the cell lines derived from various human neoplasms. "
11/01/2015 - "The qRT-PCR validation in FASN knockdown RB cells revealed up-regulation of ANXA1, DAPK2, and down-regulation of SKP2, SREBP1c, RXRA, ACACB, FASN, HMGCR, USP2a genes that favored the anti-cancer effect of lipogenic inhibition in RB. "
07/01/2015 - "Specifically, we found that death-associated protein kinase 1 (DAPK1) is essential for growth of p53-mutant cancers, which account for over 80% of TNBCs. "
|2.||Lung Neoplasms (Lung Cancer)
06/01/2014 - "We performed a meta-analysis of cohort studies to determine whether promoter methylation of the death-associated protein kinase (DAPK) gene contributes to the pathogenesis of nonsmall cell lung cancer (NSCLC). "
01/01/2009 - "Therefore, we investigated the association between the aberrant promoter methylation of 2 genes: the Death-Associated Protein Kinase (DAPK) and the Ras Association Domain Family 1A (RASSF1A) by using methylation-specific PCR, and the clinicopathological features and prognosis in 70 radically resected non-small cell lung cancers (NSCLCs). "
08/01/2003 - "Epigenetic down-regulation of death-associated protein kinase in lung cancers."
07/01/2003 - "Expression silencing through CpG island methylation of DAP-kinase has been frequently found in connection with adverse survival, as cells lacking DAP-kinase appear to be more invasive and more metastatic in lung cancer. "
09/20/2000 - "Moreover, the groups with and without hypermethylation of the DAP kinase promoter showed a striking difference in the probability of disease-specific survival; i.e., among people who died of lung cancer-related causes specifically, the probability of 5-year survival was.56 for those with such hypermethylation and.92 for those without it (P:<.001). "
|3.||Neoplasm Metastasis (Metastasis)
09/01/2014 - "Gene methylation associated with nodal metastasis included RARB (47·1 per cent for N- versus 31·7 per cent for N+; P = 0·008), chemokine ligand 12, CXCL12 (12·3 per cent for N- versus 8·9 per cent for N+; P = 0·021), and death-associated protein kinase 1, DAPK1 (19·3 per cent for N- versus 12·3 per cent for N+; P = 0·022). "
02/01/2014 - "Recent evidence has emerged that death-associated protein kinase (DAPK) is a candidate of metastasis suppressor. "
02/01/2014 - "Death-associated protein kinase (DAPK) plays an important role in apoptosis regulation and has been shown to maintain antitumor and metastasis suppressor properties. "
07/15/2012 - "We showed that miR-103/107 targeted the known metastasis suppressors death-associated protein kinase (DAPK) and Krüppel-like factor 4 (KLF4) in CRC cells, resulting in increased cell motility and cell-matrix adhesion and decreased cell-cell adhesion and epithelial marker expression. "
01/01/2004 - "Our data suggest an important role for gene methylation in the development of brain metastases, primarily involving epigenetic silencing of DAP-kinase, THBS1 and the cell-cycle regulators RB1/p16INK4a."
|4.||Breast Neoplasms (Breast Cancer)
10/01/2011 - "This study was designed to evaluate the capability of TMA for analyzing the status of death-associated protein kinase 1 (DAPK1) in breast cancer patient and to explore its potential in the management of breast cancer. "
11/15/2002 - "In a study of 134 primary breast cancer specimens hypermethylation of the DAP kinase gene was found in 13% of cases. "
06/01/2012 - "Overexpression of DAPK2 S299D also resulted in a twofold increase in apoptosis of human breast cancer MCF-7 cells as compared with wild-type DAPK2. "
10/01/2011 - "An evaluation of prognostic value of death-associated protein kinase 1 in breast cancer."
12/01/2009 - "Death-associated protein kinase (DAPK), a mediator of apoptotic systems, is silenced by promoter hypermethylation in lung and breast tumors. "
07/01/2012 - "Impaired death-associated protein kinase-mediated survival signals in 5-fluorouracil-resistant human endometrial adenocarcinoma cells."
01/01/2011 - "Specific downregulation of death-associated protein kinase enhances Fas-mediated apoptosis in the human differentiated endometrial adenocarcinoma cell line, HHUA."
10/01/2010 - "We recently showed that targeted knockdown of death-associated protein kinase (DAPK) expression induces apoptosis in the human endometrial adenocarcinoma cell line HHUA. "
07/01/2010 - "Targeted knockdown of death-associated protein kinase expression induces TRAIL-mediated apoptosis in human endometrial adenocarcinoma cells."
03/01/2007 - "Early involvement of death-associated protein kinase promoter hypermethylation in the carcinogenesis of Barrett's esophageal adenocarcinoma and its association with clinical progression."
|1.||death-associated protein kinase
|3.||DNA (Deoxyribonucleic Acid)
|5.||retinoic acid receptor beta
|8.||Messenger RNA (mRNA)
|9.||Glutathione Transferase (Glutathione S-Transferase)
|10.||Retinoic Acid Receptors (Retinoic Acid Receptor)
|1.||Drug Therapy (Chemotherapy)
|2.||Heterologous Transplantation (Xenotransplantation)