|1.||Zhang, Miqin: 15 articles (04/2015 - 06/2005)|
|2.||Veiseh, Omid: 14 articles (10/2014 - 06/2005)|
|3.||Fang, Chen: 10 articles (04/2015 - 03/2008)|
|4.||Ellenbogen, Richard G: 9 articles (10/2014 - 07/2007)|
|5.||Lee, Donghoon: 7 articles (11/2010 - 06/2005)|
|6.||Kievit, Forrest M: 6 articles (04/2015 - 02/2009)|
|7.||Sun, Conroy: 6 articles (04/2010 - 06/2005)|
|8.||Bhattarai, Narayan: 5 articles (11/2010 - 06/2005)|
|9.||Zhang, Xuan: 4 articles (10/2014 - 06/2011)|
|10.||Wang, Xueqing: 4 articles (10/2014 - 06/2011)|
04/01/2015 - "Efforts on chlorotoxin-based applications focused on producing analogues helpful for glioma diagnosis, imaging and treatment. "
03/01/2007 - "These studies demonstrated that intracavitary dosing of 131I-TM-601 appears safe, minimally toxic, and binds malignant glioma with high affinity and for long durations. "
02/01/2006 - "One Cl(-)-channel inhibitor, chlorotoxin, is currently in Phase II clinical trials to treat malignant glioma. "
01/01/2015 - "This review reports the recent advances in chlorotoxin (CTX)-targeted nanoparticles (NPs) for imaging and therapy of glioma. "
01/01/2015 - "Chlorotoxin-conjugated nanoparticles for targeted imaging and therapy of glioma."
04/01/2005 - "Nonbound 131I-TM-601 was eliminated by 48 h after injection with the remaining radiolabeled peptide bound to tumor for at least 6-8 d. "
02/10/2011 - "Bioconjugates composed of chlorotoxin and near-infrared fluorescent (NIRF) moieties are being advanced toward human clinical trials as intraoperative imaging agents that will enable surgeons to visualize small foci of cancer. "
04/01/2005 - "We evaluated imaging and biodistribution data from this trial to assess whether 131I-TM-601 might be useful in determining tumor extent. "
04/01/2015 - "Only detailed research and clinical investigations will tell us if they share the same anti-tumor potential as chlorotoxin."
04/01/2015 - "Among all the chlorotoxin-based strategies, the most promising one to enhance patient mean survival time appears to be the use of chlorotoxin as a targeting agent for the delivery of anti-tumor agents. "
|3.||Glioblastoma (Glioblastoma Multiforme)
01/01/2013 - "Tumor-targeted Chlorotoxin-coupled Nanoparticles for Nucleic Acid Delivery to Glioblastoma Cells: A Promising System for Glioblastoma Treatment."
01/01/2012 - "This study indicates that chlorotoxin fused to IgG-Fcs could be useful for the active targeting of glioblastoma cells."
01/01/2012 - "Chlorotoxin Fused to IgG-Fc Inhibits Glioblastoma Cell Motility via Receptor-Mediated Endocytosis."
01/01/2012 - "Experimental agents, like scorpion venom-derived chlorotoxin, have been successfully applied in local therapy for glioblastoma. "
|4.||Neoplasm Metastasis (Metastasis)
01/01/2014 - "Many studies have demonstrated that chlorotoxin (CTX) and Buthus martensii Karsch chlorotoxin (BmK CT) specifically inhibited glioma cells growth and metastasis, and accelerated tumor apoptosis. "
10/06/2014 - "Inhibition of metastatic tumor growth and metastasis via targeting metastatic breast cancer by chlorotoxin-modified liposomes."
|5.||Brain Neoplasms (Brain Tumor)
05/01/2014 - "These PNPs have been conjugated with a chlorotoxin, an active targeting 36-amino acid-long peptide that specifically binds to MMP-2, a receptor overexpressed by brain cancer cells. "
09/15/2013 - "Characterization of IRDye 800CW chlorotoxin as a targeting agent for brain tumors."
08/01/2006 - "TM-601 binds to malignant brain tumor cells with high affinity and does not seem to bind to normal brain tissue. "
11/01/1998 - "Use of chlorotoxin for targeting of primary brain tumors."
09/15/2013 - "We report the use of IRDye 800CW chlorotoxin (CLTX) as a targeted imaging agent for brain tumors in a spontaneous mouse model of medulloblastoma, ND2:SmoA1. "
|2.||DNA (Deoxyribonucleic Acid)
|3.||Small Interfering RNA (siRNA)
|4.||CY5.5 cyanine dye
|6.||Indicators and Reagents (Reagents)
|7.||Immunoglobulin G (IgG)
|1.||Heterologous Transplantation (Xenotransplantation)
|4.||Drug Therapy (Chemotherapy)