fragilysin

a 20 kDa zinc-containing extracellular enterotoxin implicated in diarrheal diseases; amino acid sequence given in first source

Also Known As:

B. fragilis enterotoxin; Bacteroides fragilis toxin 2; enterotoxin, Bacteroides fragilis; zinc metalloprotease, B. fragilis

Networked: 6 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Hydrolases: 2166
    - Peptide Hydrolases: 23957
      - Metalloproteases: 8276
        Metalloendopeptidases: 70
        fragilysin: 6
      - Endopeptidases: 633
        Metalloendopeptidases: 70
        fragilysin: 6

Experts

1.	AlAzmi, Ameerah: 1 article (01/2020)
2.	AlHashem, Ghayda: 1 article (01/2020)
3.	Jamal, Wafaa: 1 article (01/2020)
4.	Khodakhast, Fatima Bibi: 1 article (01/2020)
5.	Rotimi, Vincent O: 1 article (01/2020)
6.	Sόki, Jόzsef: 1 article (01/2020)
7.	Boleij, Annemarie: 1 article (01/2019)
8.	Dutilh, Bas E: 1 article (01/2019)
9.	Hermans, Susanne: 1 article (01/2019)
10.	Metz, Paul: 1 article (01/2019)

Related Diseases

1.	Carcinogenesis 01/28/2017 - "To evaluate the impact of recombinant Bacteroides fragilis enterotoxin-2 (BFT-2, or Fragilysin) on colorectal tumorigenesis in mice induced by azoxymethane/dextran sulfate sodium (AOM/DSS). " 01/01/2019 - "One of the first discovered bacterial mediators involves Bacteroides fragilis toxin (BFT, also named as fragilysin), a metalloprotease encoded by enterotoxigenic Bacteroides fragilis (ETBF) that causes barrier disruption and inflammation of the colon, leads to tumorigenesis in susceptible mice, and is enriched in the mucosa of IBD and CRC patients. "
2.	Neoplasms (Cancer) 01/01/2016 - "fragilis toxin (BFT, fragilysin) contribute to colitis and intestinal malignancy, yet are also isolated in bloodstream infection. " 11/29/2013 - "Substrate cleavage profiling suggests a distinct function of Bacteroides fragilis metalloproteinases (fragilysin and metalloproteinase II) at the microbiome-inflammation-cancer interface."
3.	Inflammation (Inflammations) 11/29/2013 - "Substrate cleavage profiling suggests a distinct function of Bacteroides fragilis metalloproteinases (fragilysin and metalloproteinase II) at the microbiome-inflammation-cancer interface." 01/01/2019 - "One of the first discovered bacterial mediators involves Bacteroides fragilis toxin (BFT, also named as fragilysin), a metalloprotease encoded by enterotoxigenic Bacteroides fragilis (ETBF) that causes barrier disruption and inflammation of the colon, leads to tumorigenesis in susceptible mice, and is enriched in the mucosa of IBD and CRC patients. "
4.	Sepsis (Septicemia) 01/01/2016 - "fragilis toxin (BFT, fragilysin) contribute to colitis and intestinal malignancy, yet are also isolated in bloodstream infection. "
5.	Diarrhea 01/01/2020 - "Some strains of Bacteroides fragilis species are associated with diarrhea as a result of enterotoxin production (bft or fragilysin). "

Related Drugs and Biologics

1.	Metalloproteases (Metalloproteinases)
2.	Dextran Sulfate
3.	Enterotoxins (Enterotoxin)
4.	Capsules (Microcapsules)
5.	Azoxymethane
6.	Bacteroides fragilis toxin