9- (3- hydroxy- 2- phosphonomethoxypropyl)- 2,6- diaminopurine

RN refers to (S)-isomer

Also Known As:

9-(3-hydroxy-2-(phosphonylmethoxy)propyl)-2,6-diaminopurine; 9-(3-hydroxy-2-phosphonomethoxypropyl)-2,6-diaminopurine, (+-)-isomer; 9-(3-hydroxy-2-phosphonomethoxypropyl)-2,6-diaminopurine, (R)-isomer; HPMPDAP

Networked: 4 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Purines: 651
      - Adenine: 2120
        9-(3-hydroxy-2-phosphonomethoxypropyl)-2,6-diaminopurine: 4
Organic Chemicals: 133
- Organophosphorus Compounds: 300
  - 9-(3-hydroxy-2-phosphonomethoxypropyl)-2,6-diaminopurine: 4

Experts

1.	De Clercq, Erik: 3 articles (10/2010 - 01/2005)
2.	Andrei, Graciela: 2 articles (10/2010 - 12/2008)
3.	Krecmerová, Marcela: 2 articles (10/2010 - 12/2008)
4.	Snoeck, Robert: 2 articles (10/2010 - 12/2008)
5.	Balzarini, Jan: 1 article (10/2010)
6.	Brehová, Petra: 1 article (10/2010)
7.	Cihlar, Tomas: 1 article (10/2010)
8.	Dracínský, Martin: 1 article (10/2010)
9.	Holý, Antoín: 1 article (10/2010)
10.	Hui, Hon: 1 article (10/2010)

Related Diseases

1.	Poxviridae Infections 10/14/2010 - "9-(S)-[3-Hydroxy-2-(phosphonomethoxy)propyl]-2,6-diaminopurine (HPMPDAP) and its cyclic form were selected for further evaluation as potential drug candidates against poxvirus infections. " 12/01/2008 - "(S)-HPMPDAP-resistant viruses were generated because this compound was shown to be one of the most highly selective and effective ANPs for the treatment of poxvirus infections. "
2.	Cowpox 12/01/2009 - "To explore this approach in greater detail, we synthesized four new compounds in this series, the ODE esters of 9-(S)-[3-hydroxy-2-(phosphonomethoxy)-propyl]guanine (HPMPG), 1-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]thymine (HPMPT), 9-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]-2,6-diaminopurine (HPMPDAP) and 9-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]-2-amino-6-cyclopropylaminopurine (HPMP-cPrDAP) and evaluated their antiviral activity against herpes simplex virus, type 1 (HSV-1), human cytomegalovirus (HCMV), and vaccinia, cowpox and ectromelia. "
3.	Vaccinia 12/01/2009 - "Against vaccinia and cowpox viruses, ODE-HPMPG and ODE-HPMPDAP were the most active and selective compounds with EC(50) values of 20-60 nM and selectivity index values of 600-3500. " 12/01/2009 - "To explore this approach in greater detail, we synthesized four new compounds in this series, the ODE esters of 9-(S)-[3-hydroxy-2-(phosphonomethoxy)-propyl]guanine (HPMPG), 1-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]thymine (HPMPT), 9-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]-2,6-diaminopurine (HPMPDAP) and 9-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]-2-amino-6-cyclopropylaminopurine (HPMP-cPrDAP) and evaluated their antiviral activity against herpes simplex virus, type 1 (HSV-1), human cytomegalovirus (HCMV), and vaccinia, cowpox and ectromelia. "
4.	Papilloma (Papillomatosis) 01/01/2005 - "The activity spectrum of cidofovir {(S)- 1-[3-hydroxy-2-(phosphonomethoxy)propyl]cytosine [(S)-HPMPC)]}, like that of (S)-HPMPA [(S)-9-[3-hydroxy-2-(phosphonomethoxy)propyl]adenine) and (S)-HPMPDAP [(S)-9-[3-hydroxy-2-(phosphonomethoxy)propyl]-2, 6-diaminopurine), encompasses a broad spectrum of DNA viruses, including polyoma-, papilloma-, adeno-, herpes-, and poxviruses. "
5.	Ectromelia (Phocomelia) 12/01/2009 - "To explore this approach in greater detail, we synthesized four new compounds in this series, the ODE esters of 9-(S)-[3-hydroxy-2-(phosphonomethoxy)-propyl]guanine (HPMPG), 1-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]thymine (HPMPT), 9-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]-2,6-diaminopurine (HPMPDAP) and 9-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]-2-amino-6-cyclopropylaminopurine (HPMP-cPrDAP) and evaluated their antiviral activity against herpes simplex virus, type 1 (HSV-1), human cytomegalovirus (HCMV), and vaccinia, cowpox and ectromelia. "

Related Drugs and Biologics

1.	Thymine
2.	Guanine
3.	Esters
4.	Cytosine
5.	Antiviral Agents (Antivirals)
6.	Adenine
7.	Cidofovir (Vistide)
8.	9- (3- hydroxy- 2- phosphonomethoxypropyl)guanine
9.	9- (S)- (3- hydroxy- 2- (phosphonomethoxy)propyl)adenine