PS 990

a neuritogenic compound; from Acremonium sp. KY12702; inhibits brain calcium/calmodulin-dependent cyclic nucleotide phosphodiesterase (CaM-PDE); structure given in first source

Also Known As:

4-((4-hydroxy-2-methoxy-3,5,6-trimethylbenzoyl)oxy)-2-hydroxy-3,5,6-trimethylbenzoic acid 4-carboxy-3-methoxy-2,5,6-trimethylphenyl ester; PS-990; Benzoic acid, 2-hydroxy-4-0((4-hydroxy-2-methoxy-3,5,6-trimethylbenzoyl)oxy)-3,5,6-trimethyl-, 4-carboxy-3-methoxy-2,5,6-trimethylphenyl ester

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Benzene Derivatives: 17
        Phenols: 677
        Hydroxybenzoates: 18
        PS 990: 2
        Benzoates: 426
        Hydroxybenzoates: 18
        PS 990: 2
- Carboxylic Acids: 973
  - Hydroxy Acids: 94
    - Hydroxybenzoates: 18
      - PS 990: 2
  - Carbocyclic Acids
    - Benzoates: 426
      - Hydroxybenzoates: 18
        PS 990: 2

Related Diseases

Neuroblastoma

07/01/1995 - "PS-990, which is a novel microbial metabolite, induced neurite formation in a murine neuroblastoma cell line, Neuro2A. "
07/01/1995 - "PS-990, a novel microbial metabolite, reversibly induces neurite extension in neuroblastoma cells."
11/01/1994 - "A novel compound, PS-990, which induces differentiation of neuroblastoma cells, was isolated from the culture broth of a fungus, Acremonium sp. KY12702. "
11/01/1994 - "PS-990 inhibited brain calcium calmodulin-dependent cyclic nucleotide phosphodiesterase with an IC50 value of 3 micrograms/ml, and markedly induced neurite extension of mouse neuroblastoma, Neuro2A, at concentrations ranging from 10 to 30 micrograms ml."

Related Drugs and Biologics

1.	Phosphoric Diester Hydrolases (Phosphodiesterases)
2.	Cyclic Nucleotides
3.	Calmodulin (Calcium-Dependent Activator Protein)
4.	Calcium