1- ((4- methylsulfonyl)phenyl)- 3- trifluoromethyl- 5- (4- fluorophenyl)pyrazole

Subscribe to Selected New Research on 1-((4-methylsulfonyl)phenyl)-3-trifluoromethyl-5-(4-fluorophenyl)pyrazole

17 relevant articles (1 outcomes, 2 trials/studies) found for this Bio-Agent

Also Known As:

SC 58125; SC-58125; 1H-Pyrazole, 5-(4-fluorophenyl)-1-04-((methylsulfonyl)phenyl)-3-(trifluoromethyl)-

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 23

1-Ring Heterocyclic Compounds

Azoles: 224

Pyrazoles: 17

1-((4-methylsulfonyl)phenyl)-3-trifluoromethyl-5-(4-fluorophenyl)pyrazole: 17

Experts

1.	Chang, Qing: 1 article (01/2005)
2.	Gong, Shusheng: 1 article (01/2005)
3.	Ding, Juan: 1 article (01/2005)

Related Diseases

1.	Hyperalgesia 01/01/1999 - "Subcutaneous injection of meloxicam or SC-58125 (selective inhibitors of cyclo-oxygenase-2) into the affected hindpaw also relieved mechanical hyperalgesia, but with a shorter time-course" 01/05/2007 - "Intrathecal administrations of the COX-2 inhibitors SC-58125 (7-100 microg) and NS-398 (7-60 microg), as well as a high dose (100 microg) of the COX-1 inhibitor SC-560 attenuated hyperalgesia, whereas intrathecal administrations of a low dose (10 microg) of SC-560 and the COX-3 inhibitor acetaminophen (1-7 mg) did not" Get all the results and reference details, order at left...
2.	Colorectal Neoplasms (Colorectal Cancer) 03/01/2004 - "In this study, human colorectal carcinoma HCT-116 cells were treated with the Cox-1 specific inhibitor SC-560 and the Cox-2 specific inhibitor SC-58125 to evaluate their ability to induce apoptosis, inhibit cell proliferation, inhibit growth on soft agar and modulate gene expression" Get all the results and reference details, order at left...
3.	Colitis 03/01/1999 - "In this study we have evaluated three highly selective COX-2 inhibitors, NS-398, SC-58125 and PD-138387, on the trinitro-benzene sulfonic acid (TNBS) model of colitis in rats" Get all the results and reference details, order at left...
4.	Neoplasms (Cancer) 09/01/2001 - "Furthermore, short-term (48 hours) treatment with SC-58125 was sufficient to attenuate tumor growth for up to 15 days" 12/01/1997 - "Intraperitoneal administration of SC-58125 suppressed RIE-Ras tumor growth in nude mice by 60.3% in 4 weeks" 09/01/1998 - "These results indicate that aberrant expression of PGHS-2 in epidermal tumors may be a relevant target for prevention of epidermal cancer development in experimental animals and that the PGHS-2-specific inhibitor SC-58125, which is a potent inhibitor of tumor promotion in mouse skin, may be important for cancer chemoprevention in humans as well." 06/01/1998 - "Furthermore, whereas antioxidants or SC 58125 reduced tumor growth in vivo, coadministration of PDTC and SC 58125 resulted in actual tumor regression" 08/01/1999 - "Tumor cell invasion was assessed with a modified Boyden collagen type I invasion assay in the presence of TGF-beta 1, antibody to urokinase plasminogen activator (uPA), or the selective cyclooxygenase-2 inhibitor SC-58125" Get all the results and reference details, order at left...
5.	Edema 06/01/1996 - "Therapeutic administration of a selective COX-2 inhibitor, SC-58125, rapidly reversed paw edema and reduced the level of PGE2 in paw tissue to baseline" 09/01/1998 - "TPA-induced edema formation, epidermal DNA synthesis, and mitotic activity were not impaired by SC-58125 applied at a dose that inhibited TPA-induced prostaglandin E2 synthesis" Get all the results and reference details, order at left...
15 Diseases and 17 more articles analyzed in the Research Interface, order at left...

Related Drugs and Biologics

1.	Prostaglandin-Endoperoxide Synthases (Cyclooxygenase)
2.	meloxicam (Mobic)
3.	Cyclooxygenase 2 Inhibitors (COX-2 Inhibitors)
4.	SC 560
5.	N- (2- cyclohexyloxy- 4- nitrophenyl)methanesulfonamide
6.	Benzene (Benzole)
7.	Agar
8.	PD 138387
9.	Dinoprostone (PGE2)
10.	Cyclooxygenase 2 (Cyclooxygenase-2)
29 Drugs and Important Bio-Agents and 16 more articles analyzed in the Research Interface, order at left...

Related Therapies and Procedures

1.	Chemoprevention
1 Therapies and Procedures and 1 more articles analyzed in the Research Interface, order at left...

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