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7- (N,N- dipropylamino)- 5,6,7,8- tetrahydronaphtho(2,3- b)dihydro- 2,3- furan
S-11566 is the (+-)-isomer; a dopamine D3 receptor antagonist
Also Known As:
S 11566; S 14297; S-11566; S-14297; Naphtho(2,3b)furan-7-amine, 2,3,5,6,7,8-hexahydro-N,N-dipropyl-, (+)-
Networked:
4
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Heterocyclic Compounds: 198
1-Ring Heterocyclic Compounds
Furans: 85
7-(N,N-dipropylamino)-5,6,7,8-tetrahydronaphtho(2,3-b)dihydro-2,3-furan: 4
Organic Chemicals: 133
Amines: 4871
2-Naphthylamine: 88
7-(N,N-dipropylamino)-5,6,7,8-tetrahydronaphtho(2,3-b)dihydro-2,3-furan: 4
Hydrocarbons: 1713
Cyclic Hydrocarbons: 97
Aromatic Hydrocarbons: 291
Polycyclic Aromatic Hydrocarbons: 2020
Naphthalenes: 18
2-Naphthylamine: 88
7-(N,N-dipropylamino)-5,6,7,8-tetrahydronaphtho(2,3-b)dihydro-2,3-furan: 4
Polycyclic Compounds: 6
Polycyclic Aromatic Hydrocarbons: 2020
Naphthalenes: 18
2-Naphthylamine: 88
7-(N,N-dipropylamino)-5,6,7,8-tetrahydronaphtho(2,3-b)dihydro-2,3-furan: 4
Related Diseases
1.
Catalepsy
11/01/1995 - "
Functional correlates of dopamine D3 receptor activation in the rat in vivo and their modulation by the selective antagonist, (+)-S 14297: 1. Activation of postsynaptic D3 receptors mediates hypothermia, whereas blockade of D2 receptors elicits prolactin secretion and catalepsy.
"
03/05/1997 - "
In contrast to haloperidol, the selective dopamine D3 receptor antagonist, (+)-S 11566 [(+/-)-[7-(N,N-dipropylamino)-5,6,7,8-tetrahydro- naphtho(2,3b)dihydro,2,3-furanel]] and its active isomer, (+)-S 14297, induced neither catalepsy nor reduced conditioned avoidance responses in rats.
"
11/01/1995 - "
Whereas haloperidol and the other antagonists provoked prolactin secretion and elicited catalepsy, (+)-S 14297 and (+/-)-S 11566 at doses of up to 10.0 and 40.0 mg/kg, s.c., respectively, were not significantly effective (P > .05).
"
10/01/1998 - "
On the other hand, haloperidol, (+)-AJ 76, (+)-UH 232 and nafadotride all induced catalepsy in rats, whereas (+)-S 14297, U 99194 and GR 103,691 were inactive.
"
2.
Hypothermia
08/01/1994 - "
These data suggest that dopamine D3 receptors mediate hypothermia in the rat and that S 14297 acts as a selective antagonist at these sites.
"
11/01/1995 - "
In conclusion, these data demonstrate that the novel naphtofurane, (+)-S 14297, is a selective ligand (antagonist) at dopamine D3 receptors and suggest that their activation mediates hypothermia in the rat.(ABSTRACT TRUNCATED AT 400 WORDS)
"
08/01/1994 - "
7-OH-DPAT (0.01-0.16 mg/kg s.c.) provoked hypothermia in rats, an action abolished by S 14297 (0.04-0.63 mg/kg s.c.) and, less potently, by AJ 76 (0.16-2.5 mg/kg s.c.).
"
08/01/1994 - "
S 14297, a novel selective ligand at cloned human dopamine D3 receptors, blocks 7-OH-DPAT-induced hypothermia in rats.
"
11/01/1995 - "
Functional correlates of dopamine D3 receptor activation in the rat in vivo and their modulation by the selective antagonist, (+)-S 14297: 1. Activation of postsynaptic D3 receptors mediates hypothermia, whereas blockade of D2 receptors elicits prolactin secretion and catalepsy.
"
Related Drugs and Biologics
1.
7- (N,N- dipropylamino)- 5,6,7,8- tetrahydronaphtho(2,3- b)dihydro- 2,3- furan
2.
Dopamine D3 Receptors
3.
Haloperidol (Haldol)
4.
Ligands
5.
5- methoxy- 1- methyl- 2- (n- propylamino)tetralin (AJ 76)
6.
Quinpirole
7.
Prolactin
8.
Clonidine (ST 155)
9.
Adrenergic Agonists (Adrenergic Receptor Agonist)
10.
nafadotride