oligopeptidase B

a trypsin-like peptidase that hydrolyzes -Arg-/ and -Lys-/ bonds in oligopeptides, even when P1' residue is proline; homolog of prolyl endopeptidase; amino acid sequence in first source

Networked: 11 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Fülöp, Vilmos: 3 articles (01/2013 - 06/2002)
2.	Morty, Rory E: 3 articles (01/2013 - 06/2002)
3.	Bastos, Izabela M D: 2 articles (01/2012 - 03/2005)
4.	Andrews, Norma W: 2 articles (04/2005 - 06/2002)
5.	Alves, Carlos Roberto: 1 article (01/2022)
6.	Barbosa, Gustavo Rolim: 1 article (01/2022)
7.	Brandt, Artur A M L: 1 article (01/2022)
8.	Conceição-Silva, Fatima: 1 article (01/2022)
9.	Cysne-Finkelstein, Lea: 1 article (01/2022)
10.	Dias-Lopes, Geovane: 1 article (01/2022)

Related Diseases

1.	African Trypanosomiasis (Nagana) 04/11/2005 - "Oligopeptidase B (OpdB) from Trypanosoma brucei is a candidate therapeutic target in African trypanosomiasis. " 01/01/2013 - "Here we present ligand-free open state and inhibitor-bound closed state crystal structures of oligopeptidase B from Trypanosoma brucei, the causative agent of African sleeping sickness. " 02/01/2010 - "Oligopeptidase B from Trypanosoma brucei (Tb OPB) is a virulence factor and therapeutic target in African sleeping sickness. "
2.	Infections 01/01/2022 - "Characterization of Leishmania (L.) amazonensis oligopeptidase B and its role in macrophage infection." 09/01/1998 - "Here we show that deletion of the gene encoding oligopeptidase B results in a marked defect in host cell invasion and in the establishment of infections in mice. " 01/01/2022 - "(V.) braziliensis clinical isolates as promastigotes growth curves, murine peritoneal macrophages infection, inflammatory mediators production, and serine proteases gene expression (subtilisin 13: S13, subtilisin 28: S28, oligopeptidase B: OPB) assessing these isolates' fitness on in vitro conditions. "
3.	Trypanosomiasis 01/01/2012 - "Oligopeptidase B, a processing enzyme of the prolyl oligopeptidase family, is considered as an important virulence factor in trypanosomiasis. " 02/01/2002 - "Prolyl oligopeptidase is involved in amnesia, depression and blood pressure control, dipeptidyl peptidase IV in type 2 diabetes and oligopeptidase B in trypanosomiasis."
4.	Chagas Disease (American Trypanosomiasis) 03/01/2005 - "Oligopeptidase B secreted by trypomastigotes and cathepsin B released upon parasite lysis retain their enzymatic activities and may be associated with Chagas' disease pathogenesis by hydrolyzing host proteins and inducing host immune responses."
5.	Visceral Leishmaniasis (Kala Azar) 03/01/2005 - "In addition, 55% and 40% of sera from kala-azar patients have antibodies to oligopeptidase B and cathepsin B, respectively. "

Related Drugs and Biologics

1.	Virulence Factors (Pathogenicity Factors)
2.	Prolyl Oligopeptidases
3.	Serine Proteases (Serine Protease)
4.	Subtilisin
5.	Dipeptidyl Peptidase 4 (Dipeptidyl Peptidase IV)
6.	Serine (L-Serine)
7.	Proteins (Proteins, Gene)
8.	Peptide Hydrolases (Proteases)
9.	Ligands
10.	Enzymes