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2-(4-hydroxyphenoxy)acetic acid-formaldehyde polymer

structure given in first source

Also Known As:

RG 13577; RG-13577

Networked: 4 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Ben-Sasson, Shmuel A: 3 articles (02/2006 - 01/2002)
2.	Vlodavsky, Israel: 3 articles (01/2003 - 01/2002)
3.	Garamvölgyi, Rita: 1 article (02/2006)
4.	Glogar, Dietmar: 1 article (02/2006)
5.	Gyöngyösi, Mariann: 1 article (02/2006)
6.	Hevesi, Akos: 1 article (02/2006)
7.	Lotan, Chaim: 1 article (02/2006)
8.	Orlowski, Michael: 1 article (02/2006)
9.	Petrasi, Zsolt: 1 article (02/2006)
10.	Pugatsch, Thea: 1 article (02/2006)

Related Diseases

1.	Hypertrophy 03/01/2002 - "In this study we clarify the mode of action of RG-13577 and demonstrate that the RG-13577-induced hypertrophy is associated with an increased expression of TGF-beta1 as indicated by an increase in TGF-beta1-specific protein and mRNA level. "
2.	Vascular System Injuries 01/01/2002 - "In this paper, the result of a continuous administration of compound RG-13577 both in the rat carotid catheter injury model and in a newly developed rat model of surgical arterial vascular injury (anastomosis) is reported: it causes a profound inhibition of intimal hyperplasia in both models. "
3.	Thrombosis (Thrombus) 02/01/2006 - "RG-13577/ATA-coated stents lead to acute stent thrombosis. " 02/01/2006 - "Five of the 6 animals receiving an RG-13577/ATA-coated stent experienced acute stent thrombosis, while no adverse events occurred in the animals of the other 2 groups. " 02/01/2006 - "Paradoxical effects of aurintricarboxylic acid and RG-13577: acute thrombosis and in-stent stenosis in a passive-coated stent."
4.	Inflammation (Inflammations) 01/15/2003 - "RG-13577, delivered intraperitoneally, inhibited the clinical signs of acute EAE and markedly ameliorated inflammation in the spinal cord, primarily by inhibiting heparanase activity in lymphocytes and astrocytes and thus impairing lymphocyte traffic. " 01/15/2003 - "RG-13577 also inhibited the tyrosine phosphorylation of several proteins, particularly Erk1 and Erk2 of the MAP kinase signaling pathways associated with inflammation and cell proliferation. " 01/15/2003 - "The immunomodulating capacity of heparin led us to test the effect of the synthetic heparin-mimicking and low anticoagulant compound RG-13577 on the course of experimental autoimmune encephalomyelitis (EAE) and central nervous system (CNS) inflammation. "
5.	Hyperplasia 01/01/2002 - "In this paper, the result of a continuous administration of compound RG-13577 both in the rat carotid catheter injury model and in a newly developed rat model of surgical arterial vascular injury (anastomosis) is reported: it causes a profound inhibition of intimal hyperplasia in both models. "

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	Transforming Growth Factor beta1 (TGF beta 1)
3.	Messenger RNA (mRNA)
4.	Tyrosine (L-Tyrosine)
5.	Heparin (Liquaemin)
6.	Aurintricarboxylic Acid
7.	Anticoagulants
8.	heparanase

Related Therapies and Procedures

1.	Catheters
2.	Stents