N,N'- bis(salicylideneamino)ethane- manganese(II)

structure given in first source

Also Known As:

EUK 8; EUK-8; salen-manganese complex; Manganese, chloro((2,2'-(1,2-ethanediylbis(nitrilomethylidyne))bis(phenolato))(2-)-N,N',O,O')-, (SP-5-13)-

Networked: 17 relevant articles (4 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Amines: 4871
  - Polyamines: 3918
    - Diamines: 518
      - Ethylenediamines: 7
        N,N'-bis(salicylideneamino)ethane-manganese(II): 17
- Organometallic Compounds: 64
  - N,N'-bis(salicylideneamino)ethane-manganese(II): 17

Experts

1.	Chatterjee, Prabal K: 3 articles (04/2003 - 01/2002)
2.	McDonald, Michelle C: 3 articles (04/2003 - 01/2002)
3.	Sharpe, Martyn A: 3 articles (04/2003 - 08/2002)
4.	Thiemermann, Christoph: 3 articles (04/2003 - 01/2002)
5.	Pinto, Aldo: 2 articles (04/2003 - 01/2002)
6.	Wayman, Nicole S: 2 articles (04/2003 - 01/2002)
7.	Molaei, Mahsa: 1 article (02/2012)
8.	Rezazadeh, Alireza: 1 article (02/2012)
9.	Yazdanparast, Razieh: 1 article (02/2012)
10.	Adachi, Souichi: 1 article (11/2009)

Related Diseases

1.	Acute Lung Injury 01/01/1996 - "Using both pre- and post-treatment designs, we have documented that treatment with EUK-8 significantly attenuates many of the features of LPS-induced acute lung injury, including arterial hypoxemia, pulmonary hypertension, decreased dynamic pulmonary compliance, and pulmonary edema. " 11/01/1995 - "Treatment with EUK-8, particularly at the higher dose, significantly attenuated many of the features of LPS-induced acute lung injury, including arterial hypoxemia, pulmonary hypertension, decreased dynamic pulmonary compliance and pulmonary edema. " 11/01/1995 - "EUK-8, a synthetic superoxide dismutase and catalase mimetic, ameliorates acute lung injury in endotoxemic swine."
2.	Inflammation (Inflammations) 02/29/2012 - "In addition, EUK-8 and EUK-134 improved steatosis, ballooning degeneration and inflammation in liver of MCD-fed rats. "
3.	Heart Failure 08/15/2006 - "The protection against pressure overload-induced heart failure in Hq mice by EUK-8 substantiates the notion that AIF functions as an important mitochondrial antioxidant in the heart. " 08/15/2006 - "EUK-8, a superoxide dismutase and catalase mimetic, reduces cardiac oxidative stress and ameliorates pressure overload-induced heart failure in the harlequin mouse mutant."
4.	Cardiomegaly (Heart Hypertrophy) 08/15/2006 - "EUK-8 also improved left ventricular end-systolic dimensions and fractional shortening, prevented myocardial oxidant stress, attenuated necrotic and apoptotic cell death, and attenuated cardiac hypertrophy and fibrosis in both mutant and WT mice. "
5.	Fibrosis (Cirrhosis) 08/15/2006 - "EUK-8 also improved left ventricular end-systolic dimensions and fractional shortening, prevented myocardial oxidant stress, attenuated necrotic and apoptotic cell death, and attenuated cardiac hypertrophy and fibrosis in both mutant and WT mice. "

Related Drugs and Biologics

1.	Catalase
2.	Superoxide Dismutase
3.	Antioxidants
4.	EUK-134
5.	Oxidants (Oxidizing Agents)
6.	Reactive Oxygen Species (Oxygen Radicals)
7.	Oxygen (Dioxygen)
8.	Endotoxins
9.	Secretory Phospholipases A2
10.	Chemokine CXCL1

Related Therapies and Procedures

1.	Hormone Replacement Therapy (Therapy, Hormone Replacement)
2.	Therapeutics
3.	Resuscitation