|1.||Habib, Samy L: 14 articles (08/2014 - 01/2008)|
|2.||Rosner, Margit: 9 articles (08/2013 - 12/2003)|
|3.||Hengstschläger, Markus: 9 articles (08/2013 - 12/2003)|
|4.||Yeung, Raymond S: 8 articles (11/2010 - 08/2002)|
|5.||Blenis, John: 7 articles (09/2013 - 07/2002)|
|6.||Hino, Okio: 7 articles (08/2013 - 11/2002)|
|7.||Walker, Cheryl Lyn: 7 articles (05/2010 - 03/2002)|
|8.||Mizuguchi, Masashi: 7 articles (03/2007 - 01/2002)|
|9.||Henske, Elizabeth Petri: 6 articles (09/2013 - 12/2003)|
|10.||Kobayashi, Toshiyuki: 6 articles (08/2013 - 11/2002)|
|1.||Tuberous Sclerosis (Bourneville's Disease)
09/15/2011 - "Mimicking a mutation found in a subset of patients with tuberous sclerosis, we found a significant reduction in the binding between tuberin and cyclin B1. "
08/01/2013 - "Recent studies indicated that the tuberous sclerosis 2 (TSC2) gene product, tuberin, regulates Rac1 activity. "
06/01/2014 - "The TSC2 gene, mutated in patients with tuberous sclerosis complex (TSC), encodes a 200 kDa protein TSC2 (tuberin). "
06/01/2012 - "regulatory Thr/Tyr in Erks 1 and 2, Tyr in signal transducers and activators of transcription (Stat) 5a and 5b, Ser939 in tuberous sclerosis protein (TSC) 2 or tuberin). "
01/01/2012 - "Impaired social interactions and motor learning skills in tuberous sclerosis complex model mice expressing a dominant/negative form of tuberin."
05/01/2008 - "In tumors that retained TSC2 expression, phosphorylation of tuberin at S939 was observed with a high frequency, indicating that mTOR repression by TSC2 had been relieved via AKT phosphorylation of this tumor suppressor. "
05/15/2014 - "In addition, a significant increase in phospho-Akt/tuberin expression was associated with an increase in Ki67 expression and activation of mTOR in kidney tumor with or without diabetes compared to diabetes alone. "
08/01/2013 - "To better understand the molecular link between tuberin function and Rac1, we characterized the activity and distribution of Rac1 in mouse Tsc2-deficient renal tumor cells using restoration experiments with wild-type tuberin. "
06/01/2013 - "This was accompanied by an inhibitory shift in the Akt/mTOR signaling pathway which included diminished expression and/or phosphorylation of Akt, mTOR, p70 S6K, and p85 S6K with increased activation of AMPKα and the tumor suppressor tuberin/TSC2. "
03/01/2012 - "These data allow new insights into the regulation of early stem-cell maintenance and differentiation and identify a new role of the tumor suppressor tuberin and the oncogenic protein PRAS40 with the relevance for a more detailed understanding of the pathogenesis of diseases associated with altered activities of these gene products."
|3.||Breast Neoplasms (Breast Cancer)
07/01/2005 - "Tumours from patients who developed recurrence and died from breast cancer had significantly low levels of tuberin compared with those who remained disease free (P = 0.03 and 0.05, respectively). "
08/01/2013 - "Our results suggest that tuberin and p27 are aberrantly expressed in malignant tissue, but their expression does not appear to be dependent on the BRCA mutation state of a breast cancer patient."
08/01/2013 - "The expression of tuberin and p27 in breast cancer was not correlated with clinical outcome. "
08/01/2013 - "Tuberin and p27 protein expression were significantly more common in benign when compared to malignant breast tissue (p = 0.01 and p = 0.03), but no difference was observed when sporadic and BRCA-mutated breast cancer specimen were compared. "
08/01/2013 - "immunohistochemistry was used to compare p27 and tuberin protein expression in 26 BRCA1 and 2 mutation carriers, in 53 matched breast cancer patients without a family history, and in 74 benign breast tissues in a case-control study. "
|4.||Astrocytoma (Pilocytic Astrocytoma)
01/01/2003 - "In this study, we compared levels of Rap1-GTP, Rap1 and tuberin levels in normal brain tissue and 24 grade II-IV astrocytoma specimens. "
09/25/1997 - "Previous studies from our laboratory demonstrated that 30% of sporadic astrocytomas have reduced or absent tuberin expression. "
02/01/2004 - "The subependymal giant cell astrocytomas of six of nine patients had no expression of tuberin as well, whereas three patients retained some tuberin expression. "
12/01/2003 - "Subependymal giant cell astrocytoma with positive tuberin expression--case report."
01/01/2003 - "Whereas Rap1 overexpression was observed in astrocytomas of all malignancy grades, tuberin loss was seen most frequently in the higher-grade astrocytomas. "
08/30/2014 - "In the present study, we investigated the role of Akt/tuberin/mTOR pathway in the regulation cell fibrosis proteins. "
01/01/2013 - "In the present study, we investigated the potential role of tuberin/mTOR pathway in the regulation of cell fibrosis in AML cells and kidney tumor tissue from tuberous sclerosis complex (TSC) patients. "
01/01/2013 - "The mechanisms by which tuberin regulates fibrosis in kidney angiomyolipomas (AMLs) of tuberous sclerosis patients are not fully known. "
09/05/2005 - "Patients with tuberous sclerosis complex (TSC) develop hamartomatous tumors showing loss of function of the tumor suppressor TSC1 (hamartin) or TSC2 (tuberin) and increased angiogenesis, fibrosis, and abundant mononuclear phagocytes. "
08/30/2014 - "These data comprise the first report to provide the role of Akt/tuberin/mTORC1/2 in the regulation of N-cadherin and vimentin that are involved in the progression of fibrosis in kidney tumor of TSC patients. "
|1.||tuberous sclerosis complex 1 protein (hamartin)
|2.||Proteins (Proteins, Gene)
|5.||Staphylococcal Protein A (A, Protein)
|6.||Messenger RNA (mRNA)
|9.||AMP-Activated Protein Kinases
|10.||Protein Kinases (Protein Kinase)
|1.||Heterologous Transplantation (Xenotransplantation)