ponicidin

06/01/2023 - "Furthermore, Ponicidin suppressed tumor growth in the nude mouse model of GBC with excellent safety. "
06/01/2023 - "Moreover, Ponicidin exerted anti-tumor effects by down-regulating the expression of MAGEB2. "
06/01/2023 - "Nude mouse model of GBC was used to assess the anti-tumor effect and safety of Ponicidin. "
05/01/2019 - "In conclusion, ponicidin might be a promising plant-derived cancer chemotherapeutic agent."
02/01/2007 - "Ponicidin is recently reported to have anti-tumour effects on a large variety of cancers. "

04/01/2022 - "The ponicidin treatment effectively decreased the body weight, food intake, HOMA-IR, and HbAlc levels in the DN animals. "
02/01/2023 - "Ponicidin significantly (P < 0.001) repressed the glucose level and water food intake and improved the body weight and plasma insulin. "

11/24/2023 - "Ponicidin-induced conformational changes of HSP90 regulates the MAPK pathway to relieve ulcerative colitis."
11/24/2023 - "2.5% (w/v) dextran sulfate sodium (DSS) was used to induce C57BL/6 mice to form an ulcerative colitis model, and then 5 mg/kg and 10 mg/kg ponicidin was given for treatment, while the Rabdosia rubescens extract group and Rabdosia rubescens diterpene extract group were set up for comparison of the efficacy of ponicidin. "

11/01/2008 - "In this study two monocytic leukemia cell lines, U937 and THP-1 cells, were used to investigate the anti-proliferation effects caused by ponicidin. "
08/01/2010 - "[Apoptosis inducing effect of ponicidin in leukemia K562 cells and its mechanisms of action]."
11/01/2008 - "The results suggest that ponicidin may serve as potential therapeutic agent for leukemia."
11/01/2008 - "Ponicidin inhibits monocytic leukemia cell growth by induction of apoptosis."
04/01/2005 - "The results suggest that ponicidin may serve as a potential therapeutic agent for leukemia."

10/01/2015 - "The present study aimed to determine the antitumor effects of ponicidin, and to investigate its underlying mechanisms in colorectal cancer. "
10/01/2015 - "The HT29 colorectal cancer cell line was used to detect the cytotoxicity of various doses of ponicidin. "
10/01/2015 - "In conclusion, ponicidin acted as an inducer of apoptosis, and may be used as a therapeutic cytotoxic drug to treat human cancer, including colorectal cancer."
06/01/2019 - "Ponicidin (PON), a natural diterpenoid compound, has been shown to exhibit potent anticancer activities in a wide variety of cancers, including colorectal cancer (CRC). "
06/01/2019 - "Ponicidin inhibits pro-inflammatory cytokine TNF-α-induced epithelial-mesenchymal transition and metastasis of colorectal cancer cells via suppressing the AKT/GSK-3β/Snail pathway."