AK 295

a dipeptide alpha-ketoamide calpain inhibitor

Also Known As:

AK-295; AK295; CX 295; CX-295; CX295 cpd; Cbz-Leu-Abu-CONH(CH2)3-Mpl; Cbz-Leu-aminobutyrate-CONH(CH2)3-morpholine; Z-Leu-aminobutyric acid-CONH(CH2)3-morpholine; Carbamic acid, (1-(((1-ethyl-3-((3-(4-morpholinyl)propyl)amino)-2,3-dioxopropyl)amino)carbonyl)-3-methylbutyl)-, phenylmethyl ester, stereoisomer

Networked: 5 relevant articles (2 outcomes, 2 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Peptides: 82426
  - Oligopeptides: 519
    - Dipeptides: 945
      - AK 295: 5

Experts

1.	Akdemir, O: 1 article (06/2009)
2.	Celik, O: 1 article (06/2009)
3.	Colak, A: 1 article (06/2009)
4.	Karaoğlan, A: 1 article (06/2009)
5.	Kaya, M: 1 article (06/2009)
6.	Sahan, E: 1 article (06/2009)
7.	Sağmanligil, A: 1 article (06/2009)
8.	Ahrend, M H: 1 article (12/2000)
9.	Breipohl, W: 1 article (12/2000)
10.	Gupta, S K: 1 article (12/2000)

Related Diseases

1.	Wounds and Injuries (Trauma) 06/01/2009 - "One hour after having been subjected to that trauma, the rats in groups 2 and 3 were treated with an intraperitoneal injection of either dimethyl sulfoxide 2 mg/kg or AK 295 2 mg/kg. The effects of the injury and the efficacy of AK 295 were determined by an assessment of the TUNEL technique and the results of examination with a light microscope. "
2.	Cataract (Cataracts) 12/01/2000 - "AK295, SJA6017 and MDL28170 possess efficacy against calcium-induced models of rodent cataracts. "
3.	Brain Injuries (Brain Injury) 04/16/1996 - "Calpain inhibitor AK295 attenuates motor and cognitive deficits following experimental brain injury in the rat." 01/01/2000 - "These data suggest that an overt reduction in spectrin proteolysis, cortical lesion, or apoptotic cell death at 48 hours or 1 week is not required for behavioral improvements associated with calpain inhibition by AK295 after experimental brain injury in rats." 04/16/1996 - "In this study, we evaluated the effect of the calpain inhibitor AK295 [Z-Leu-aminobutyric acid-CONH(CH2)3-morpholine] on cognitive and motor deficits following lateral fluid percussion brain injury in rats. "
4.	Spinal Cord Injuries (Spinal Cord Injury) 06/01/2009 - "In this study, we evaluated the effect of a calpain inhibitor, AK 295, on spinal cord structure, neurologic function, and apoptosis after spinal cord injury (SCI) in a murine model. " 06/01/2009 - "Thirty albino Wistar rats were divided into 3 groups of 10 each: the sham-operated control group (group 1), the spinal cord trauma group (group 2), and the spinal cord trauma plus AK 295 treatment group (group 3). " 06/01/2009 - "Calpain inhibitor AK 295 inhibits calpain-induced apoptosis and improves neurologic function after traumatic spinal cord injury in rats."
5.	Cognitive Dysfunction 01/01/2000 - "Administration of the selective calpain inhibitor AK295 has been shown to attenuate motor and cognitive dysfunction after brain trauma in rats. "

Related Drugs and Biologics

1.	Dimethyl Sulfoxide (DMSO)
2.	Calcium
3.	N- (4- fluorophenylsulfonyl)- L- valyl- L- leucinal
4.	calpain inhibitor III
5.	calpain inhibitors
6.	Aminobutyrates (Aminobutyric Acid)
7.	morpholine
8.	Calpain
9.	Neuroprotective Agents
10.	Spectrin

Related Therapies and Procedures

1.	Intraperitoneal Injections