|1.||Sağmanligil, A: 1 article (06/2009)|
|2.||Colak, A: 1 article (06/2009)|
|3.||Kaya, M: 1 article (06/2009)|
|4.||Sahan, E: 1 article (06/2009)|
|5.||Akdemir, O: 1 article (06/2009)|
|6.||Celik, O: 1 article (06/2009)|
|7.||Karaoğlan, A: 1 article (06/2009)|
|8.||Sharma, Y D: 1 article (12/2000)|
|9.||Ahrend, M H: 1 article (12/2000)|
|10.||Breipohl, W: 1 article (12/2000)|
|1.||Wounds and Injuries (Trauma)
06/01/2009 - "One hour after having been subjected to that trauma, the rats in groups 2 and 3 were treated with an intraperitoneal injection of either dimethyl sulfoxide 2 mg/kg or AK 295 2 mg/kg. The effects of the injury and the efficacy of AK 295 were determined by an assessment of the TUNEL technique and the results of examination with a light microscope. "
|3.||Brain Injuries (Brain Injury)
01/01/2000 - "Administration of the selective calpain inhibitor AK295 has been shown to attenuate motor and cognitive dysfunction after brain trauma in rats. "
04/16/1996 - "Calpain inhibitor AK295 attenuates motor and cognitive deficits following experimental brain injury in the rat."
01/01/2000 - "These data suggest that an overt reduction in spectrin proteolysis, cortical lesion, or apoptotic cell death at 48 hours or 1 week is not required for behavioral improvements associated with calpain inhibition by AK295 after experimental brain injury in rats."
04/16/1996 - "In this study, we evaluated the effect of the calpain inhibitor AK295 [Z-Leu-aminobutyric acid-CONH(CH2)3-morpholine] on cognitive and motor deficits following lateral fluid percussion brain injury in rats. "
|4.||Spinal Cord Injuries (Spinal Cord Injury)
06/01/2009 - "In this study, we evaluated the effect of a calpain inhibitor, AK 295, on spinal cord structure, neurologic function, and apoptosis after spinal cord injury (SCI) in a murine model. "
06/01/2009 - "Thirty albino Wistar rats were divided into 3 groups of 10 each: the sham-operated control group (group 1), the spinal cord trauma group (group 2), and the spinal cord trauma plus AK 295 treatment group (group 3). "
06/01/2009 - "Calpain inhibitor AK 295 inhibits calpain-induced apoptosis and improves neurologic function after traumatic spinal cord injury in rats."
11/01/1994 - "The highest dose tested (3 mg/kg per hour) afforded the maximum effect, illustrated by a 32% reduction in infarct volume 21 hours after the ischemia (vehicle, 81.7 +/- 4.7 mm3; AK295, 54.9 +/- 6.9 mm3; P < .007). "
11/01/1994 - "Postocclusion (1.25-hour) infusion of the calpain inhibitor AK295 elicited a dose-dependent neuroprotective effect after focal ischemia. "
|1.||Dimethyl Sulfoxide (DMSO)
|3.||N- (4- fluorophenylsulfonyl)- L- valyl- L- leucinal
|4.||calpain inhibitor III
|6.||Aminobutyric Acids (Aminobutyric Acid)
|10.||salicylhydroxamic acid (SHAM)