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IEM 1078
binds irreversibly to nicotinic acetylcholine receptors; structure in first source
Also Known As:
IEM-1078; IEM-1678; t-butyldecylammonium; tert-bytyldecylammonium chloride
Networked:
2
relevant articles (
1
outcomes,
0
trials/studies)
Relationship Network
Bio-Agent Context: Research Results
Inorganic Chemicals: 9
Nitrogen Compounds: 67
Ammonium Compounds: 1606
Quaternary Ammonium Compounds: 136
IEM 1078: 2
Organic Chemicals: 133
Amines: 4871
Quaternary Ammonium Compounds: 136
IEM 1078: 2
Onium Compounds
Quaternary Ammonium Compounds: 136
IEM 1078: 2
Experts
1.
Gmiro, V E
: 2 articles (07/2008 - 05/2007)
2.
Serdiuk, S E
: 1 article (07/2008)
3.
Serdyuk, S E
: 1 article (05/2007)
Related Diseases
1.
Seizures (Absence Seizure)
07/01/2008 - "
However, even in the maximum dose of 3 mg/kg, IEM-1678 only slightly decreases kainate clonic-tonic seizures.
"
05/01/2007 - "
IEM-1678, an alpha3beta4 nicotinic acetylcholine receptor antagonist administered intramuscularly in a maximum dose of 3 mg/kg decreased the incidence of kainate-induced tonic-clonic seizures and mortality rate by 2.3-2.7.
"
Related Drugs and Biologics
1.
Kainic Acid (Kainate)
2.
Nicotinic Receptors (Nicotinic Acetylcholine Receptor)