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LEK 8829

structure given in first source; RN given refers to monomethanesulfonate salt

Also Known As:

9,10-didehydro-N-methyl-N-(2-propynyl)-6-methyl-8beta-aminomethylergoline; LEK-8829

Networked: 5 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Alkaloids: 5398
  - Ergot Alkaloids: 208
    - Ergolines: 109
      - Lysergic Acid: 42
        LEK 8829: 5
- Fused-Ring Heterocyclic Compounds
  - 4 or More Rings Heterocyclic Compounds
    - Ergolines: 109
      - Lysergic Acid: 42
        LEK 8829: 5

Experts

1.	Krisch, Igor: 1 article (06/2004)
2.	Milivojevic, Natasa: 1 article (06/2004)
3.	Sket, Dusan: 1 article (06/2004)
4.	Zivin, Marko: 1 article (06/2004)

Related Diseases

1.	Psychotic Disorders (Schizoaffective Disorder) 11/01/1996 - "We conclude, therefore, that the putative atypical antipsychotic LEK-8829 may prove useful as an experimental tool for the study of D1:D2 receptor interactions and could have beneficial effects in the treatment of drug-induced psychosis in patients with Parkinson's disease." 05/22/1998 - "Therefore, LEK-8829 may have a potential for the therapy of parkinsonism complicated by dopamine D2 receptor agonist drug-induced psychosis."
2.	Cocaine-Related Disorders (Cocaine Addiction) 06/01/2004 - "The results of our study indicate that LEK-8829 is a candidate medication for the treatment of cocaine craving in cocaine addiction."
3.	Parkinson Disease (Parkinson's Disease) 11/01/1996 - "We conclude, therefore, that the putative atypical antipsychotic LEK-8829 may prove useful as an experimental tool for the study of D1:D2 receptor interactions and could have beneficial effects in the treatment of drug-induced psychosis in patients with Parkinson's disease."
4.	Parkinsonian Disorders (Parkinsonism) 05/22/1998 - "Therefore, LEK-8829 may have a potential for the therapy of parkinsonism complicated by dopamine D2 receptor agonist drug-induced psychosis."
5.	Tremor (Tremors) 10/01/1994 - "In the case of LEK-8829, nonspecific effects that presumably predict a side effect profile, such as potentiation of pentobarbital-induced anesthesia in mice (sedation), antagonism of oxotremorine-induced tremors in mice (anticholinergic activity), spontaneous locomotor activity in mice and norepinephrine-induced lethality in rats (sedation and hypotension), were relatively weak compared with the activities described earlier. "

Related Drugs and Biologics

1.	Antipsychotic Agents (Antipsychotics)
2.	Cocaine (Cocaine HCl)
3.	Cholinergic Antagonists (Anticholinergics)
4.	Dopamine D2 Receptors (Dopamine D2 Receptor)
5.	Pentobarbital (Nembutal)
6.	Oxotremorine
7.	Norepinephrine (Noradrenaline)
8.	Haloperidol (Haldol)
9.	Clozapine (Clozaril)
10.	Apomorphine

Related Therapies and Procedures

1.	Therapeutics
2.	Anesthesia