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OLX 209

a recombinant toxin; a fusion protein consisting of a single chain antibody and a modified Pseudomonas exotoxin

Also Known As:

OLX-209

Networked: 2 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Biological Factors: 2472
- Biological Toxins: 20
  - Exotoxins: 1439
    - OLX 209: 2
Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
- Peptides: 82426
  - Peptide Fragments: 373
    - Immunoglobulin Fragments: 976
      - Immunoglobulin Fab Fragments: 769
        Immunoglobulin Variable Region: 208
        Single-Chain Antibodies: 852
        OLX 209: 2

Related Diseases

1.	Lung Neoplasms (Lung Cancer) 01/01/1996 - "This study demonstrates that OLX-209 has activity on lung cancer cells with varying levels of erbB-2 expression in the presence and absence of gene amplification. " 01/01/1996 - "Activity of anti-erbB-2 recombinant toxin OLX-209 on lung cancer cell lines in the absence of erbB-2 gene amplification."
2.	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 01/01/1996 - "The results of this study indicate that patients with erbB-2-positive, non-small cell lung cancer should be included in clinical trials of OLX-209."
3.	Neoplasms (Cancer) 01/01/1996 - "The recombinant oncotoxin OLX-209 [e23(Fv)PE38KDEL] has been developed to target cancers with erbB-2 expression and is nearing a clinical trial. " 11/01/1996 - "The recombinant oncotoxin AR209 [e23(Fv)PE38KDEL; formerly OLX-209] was developed to treat neoplasia that expresses the c-erbB-2 (HER-2/neu) protein product p185(erbB-2). "

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)