|1.||Lewis, Jason S: 11 articles (02/2010 - 11/2002)|
|2.||Jeraj, Robert: 10 articles (07/2015 - 03/2009)|
|3.||Fujibayashi, Yasuhisa: 9 articles (09/2015 - 11/2002)|
|4.||Furukawa, Takako: 7 articles (09/2015 - 08/2006)|
|5.||Welch, Michael J: 7 articles (08/2008 - 11/2002)|
|6.||Dilworth, Jonathan R: 6 articles (05/2015 - 05/2008)|
|7.||Bentzen, Søren M: 5 articles (10/2012 - 03/2009)|
|8.||Lewis, J S: 5 articles (04/2009 - 03/2001)|
|9.||Yoshii, Yukie: 4 articles (09/2015 - 02/2012)|
|10.||Blower, Philip J: 4 articles (12/2014 - 02/2005)|
04/01/2001 - "These data confirm that Cu-ATSM uptake in tissues in vivo is dependent on the tissue pO2, and that significantly greater uptake and retention occur in hypoxic tumor tissue. "
08/01/2006 - "In our study, it was revealed that one tumor mass contained two regions with different characteristics, which could be distinguished by [(64)Cu]Cu-ATSM and [(18)F]FDG. "
08/01/2006 - "The immunohistochemical study demonstrated that the high [(64)Cu]Cu-ATSM uptake regions were hypovascular and consisted of tumor cells arrested in the cell cycle, whereas the high [(18)F]FDG uptake regions were hypervascular and consisted of proliferating cells. "
04/01/2001 - "This study was undertaken to confirm the pO2 dependence of this selective uptake in vivo by correlating Cu-ATSM uptake with measured tumor pO2. "
01/01/2016 - "Larger tumor diameter, high neutrophil-to-lymphocyte ratio and advanced pathological stage were also associated with accumulation of hypoxic PETs ((18)F-FAZA, p<0.01; (62)Cu-ATSM, p<0.04), but not with that of (18)F-FDG. "
09/01/2015 - "Both similar and different intratumoral distributions of these PET tracers have been reported with some studies questioning the dependence of the Cu-ATSM accumulation on hypoxia. "
10/01/2013 - "This apparatus allows the conduction of radiotracer uptake studies in cells under complete atmospheric control, as evidenced by our first demonstration of the hypoxia-dependent uptake of Cu-ATSM in ventricular myocytes. "
05/01/2009 - "The purpose of this study is to reveal characteristics of (64)Cu-labeled diacetyl-bis(N(4)-methylthiosemicarbazone) ([(64)Cu]Cu-ATSM) during cell proliferation and hypoxia by autoradiography imaging and immunohistochemical staining. "
07/01/1997 - "In this study, Cu(II)-diacetyl-bis(N4-methylthiosemicarbazone) (Cu-ATSM), a 62Cu-bisthiosemicarbazone complex, with high membrane permeability and low redox potential, was evaluated as a possible hypoxia imaging agent, using electron spin resonance spectrometry and the Langendorff isolated perfused rat heart model as well as rat heart left anterior descending occlusion model. "
09/01/2015 - "Our findings indicate that intratumoral distributions of FAZA and Cu-ATSM were essentially non-overlapping and although hypoxia affects the buildup of both tracers, the accumulation of Cu-ATSM occurred at milder hypoxia compared to the conditions required for the accumulation of FAZA. "
|4.||Head and Neck Neoplasms (Head and Neck Cancer)
03/01/2012 - "Thirty patients with head-and-neck cancer underwent Cu-ATSM and FDG PET within a 1 week interval. "
10/01/2010 - "A head & neck cancer patient underwent a [(61)Cu]Cu-ATSM PET/CT-scan. "
01/01/2014 - "Eleven patients with head and neck cancer treated with chemoradiotherapy were enrolled prospectively; both Cu-ATSM and F-FDG PET/CT scans before and after treatment were obtained. "
03/01/2012 - "The 2 tracers represented different pathophysiological microenvironments in different tumors, suggesting that noninvasive hypoxic tissue imaging with Cu-ATSM would be beneficial in the pretreatment evaluation of head-and-neck cancer."
03/01/2012 - "In patients with head-and-neck cancer, intratumoral distribution of Cu-ATSM and FDG showed a negative correlation in SCC and a positive correlation in adenocarcinoma. "
|5.||Squamous Cell Carcinoma (Epidermoid Carcinoma)
08/01/2011 - "Additionally, calculated PO(2) distributions from imaged Cu-ATSM tracer activity concentrations of 12 head and neck squamous cell carcinoma (HNSCC) patients were validated against microelectrode PO(2) measurements in 69 HNSCC patients. "
09/01/2014 - "The intratumoral distributions of [(18)F]FDG and [(64)Cu]Cu-ATSM have been reported to be similar in adenocarcinomas but different in squamous cell carcinoma (SCC) in clinical studies. "
03/01/2012 - "The SUV mean of Cu-ATSM was lower than that of FDG for both squamous cell carcinoma (SCC) and adenocarcinoma (P < 0.05). "
04/01/2007 - "The influence of tumor oxygenation on hypoxia imaging in murine squamous cell carcinoma using [64Cu]Cu-ATSM or [18F]Fluoromisonidazole positron emission tomography."
|4.||Deoxyglucose (2 Deoxy D glucose)
|8.||Fluorodeoxyglucose F18 (Fludeoxyglucose F 18)
|9.||copper pyruvaldehyde bis(N(4)-methylthiosemicarbazone) complex
|10.||Cytochrome-B(5) Reductase (Methemoglobin Reductase)
|2.||Heterologous Transplantation (Xenotransplantation)