3'- angeloyloxy- 4'- acetoxy- 3',4'- dihydroseselin

a pyranocoumarin compound; isolated from a Chinese medicinal plant Bai-Hua Qian-Hu; structure given in first source; RN given refers to compound with no isomeric designation

Also Known As:

(9alpha(Z),10alpha)-(+-) of 3'-angeloyloxy-4'-acetoxy-3',4'-dihydroseselin; 9R-(9alpha(Z),10alpha) of 3'-angeloyloxy-4'-acetoxy-3',4'-dihydroseselin; 9S-(9alpha(Z),10alpha) of 3'-angeloyloxy-4'-acetoxy-3',4'-dihydroseselin; 9alpha(E),10alpha of 3'-angeloyloxy-4'-acetoxy-3',4'-dihydroseselin; 9alpha(E),10beta of 3'-angeloyloxy-4'-acetoxy-3',4'-dihydroseselin; Pd-Ia

Networked: 9 relevant articles (0 outcomes, 4 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrans: 130
    - Benzopyrans: 195
      - Coumarins: 826
        3'-angeloyloxy-4'-acetoxy-3',4'-dihydroseselin: 9
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Benzopyrans: 195
      - Coumarins: 826
        3'-angeloyloxy-4'-acetoxy-3',4'-dihydroseselin: 9

Experts

1.	Zhang, Z: 2 articles (04/2011 - 01/2011)
2.	Zhu, X: 2 articles (04/2011 - 01/2011)
3.	Chang, Tian-Hui: 2 articles (01/2004 - 09/2002)
4.	Wang, Huai-Liang: 2 articles (01/2004 - 09/2002)
5.	Zhang, Xin-Hua: 2 articles (01/2004 - 09/2002)
6.	Liang, X F: 1 article (04/2011)
7.	Liu, Y Y: 1 article (04/2011)
8.	Su, M Q: 1 article (04/2011)
9.	Wang, W F: 1 article (04/2011)
10.	Li, Lp: 1 article (01/2011)

Related Diseases

1.	Ischemia 09/01/1994 - "Effects of 3'-angeloyloxy-4'-acetoxy-3',4'-dihydroseselin on myocardial dysfunction after a brief ischemia in anesthetized dogs." 06/02/1994 - "We examined the effect of Pd-Ia on cardiohemodynamics and regional myocardial dysfunction after transient ischemia in anesthetized open-chest dogs. " 12/20/2007 - "The purpose of this study was, for the first time, to evaluate the in vivo effects of Pd-Ia on IF desmin and vimentin content in order to further explore its cardioprotection against ischemia and elucidate its mechanism of action. " 12/20/2007 - "Pd-Ia protectively increased IF desmin and vimentin content in ischemia/reperfusion myocardiocytes, which might be partially responsible for its cardioprotection against ischemia." 12/20/2007 - "Pretreatment with i.v. infusion of Pd-Ia prior to ischemia significantly increased desmin and vimentin content and alleviated defects caused by the ischemia/reperfusion insult, e.g. "
2.	Experimental Liver Cirrhosis 01/01/2011 - "In the present study, the influence of liver cirrhosis on pharmacokinetics of Pd-Ia and hepatic mRNA expression of CYP3A1 and 3A2 in rats with experimental liver cirrhosis (LC rats) were evaluated. "
3.	Liver Cirrhosis (Hepatic Cirrhosis) 01/01/2011 - "In the present study, the influence of liver cirrhosis on pharmacokinetics of Pd-Ia and hepatic mRNA expression of CYP3A1 and 3A2 in rats with experimental liver cirrhosis (LC rats) were evaluated. "
4.	Hypertrophy 05/01/2009 - "The present study investigated whether dl-praeruptorin (Pd-Ia) prevents endothelin-1 (ET-1)-induced cardiomyocyte hypertrophy and the potential pathways that underlie such an effect. "
5.	Heart Diseases (Heart Disease) 04/15/2011 - "dl-Praeruptorin A (Pd-Ia), isolated from Chinese traditional herbal medicine Peucedanum praeruptorum Dunn, has been proved to be a novel Ca²+-influx blocker and K+-channel opener, and displayed bright prospects in prevention and therapy of cardiac diseases. " 01/01/2011 - "As a novel drug in the treatment of cardiac diseases, dl-praeruptorin A (Pd-Ia) is the major active component of traditional herbal medicine Peucedanum praeruptorum Dunn and is metabolized primarily via cytochrome P450 isozymes (CYP) 3A1 and 3A2 in rats. "

Related Drugs and Biologics

1.	praeruptorin A
2.	Endothelin-1 (Endothelin 1)
3.	NF-kappa B (NF-kB)
4.	Vimentin
5.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
6.	Messenger RNA (mRNA)
7.	Desmin
8.	Proteins (Proteins, Gene)
9.	Interleukin-6 (Interleukin 6)
10.	Isoenzymes

Related Therapies and Procedures

1.	Therapeutics