HOME
PRODUCTS
COMPANY
CONTACT
FAQ
Research
Dictionary
Pharma
Sign Up
FREE
or
Login
Username:
Password:
Remember login
Login
Send password reminder...
NPC 14695
a smooth muscle-selective muscarinic antagonist in vivo; structure given in first source
Also Known As:
3-(4-benzylpiperazinyl)-1-cyclobutyl-1-hydroxy-1-phenyl-2-propanone; NPC-14695
Networked:
1
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Organic Chemicals: 133
Hydrocarbons: 1713
Cyclic Hydrocarbons: 97
Alicyclic Hydrocarbons: 1
Cycloparaffins: 6
Cyclobutanes
NPC 14695: 1
Heterocyclic Compounds: 198
1-Ring Heterocyclic Compounds
Piperazines: 26
NPC 14695: 1
Related Diseases
1.
Mydriasis
08/01/1994 - "
At doses that produced a maximum bronchodilation, the two drugs produced an equivalent inhibition of salivation and NPC-14695 produced mydriasis.
"
08/01/1994 - "
administration in conscious guinea pigs challenged with aerosolized carbachol, NPC-14695 was more potent in the inhibition of collapse than in the inhibition of salivation or the production of mydriasis.
"
2.
Tachycardia (Tachyarrhythmias)
08/01/1994 - "
At increasing equieffective bronchodilator doses of aerosolized ipratropium and intraduodenally administered NPC-14695 in anesthetized guinea pigs infused with methacholine, ipratropium reversed the bradycardia and then produced tachycardia whereas NPC-14695 did not alter the heart rate.
"
3.
Bradycardia
08/01/1994 - "
NPC-14695 was more M3/M2 selective than diphenyl-acetoxy-4-methylpiperidine methiodide (4-DAMP) in vivo, which was determined from the reversal of bronchoconstriction and bradycardia after i.v. administration in anesthetized guinea pigs infused with methacholine, but was less potent than ipratropium or 4-DAMP.
"
08/01/1994 - "
At increasing equieffective bronchodilator doses of aerosolized ipratropium and intraduodenally administered NPC-14695 in anesthetized guinea pigs infused with methacholine, ipratropium reversed the bradycardia and then produced tachycardia whereas NPC-14695 did not alter the heart rate.
"
Related Drugs and Biologics
1.
Methacholine Chloride (Methacholine)
2.
Ipratropium (Ipratropium Bromide)
3.
Carbachol (Carbastat)
4.
Bronchodilator Agents (Bronchodilators)
5.
4- diphenylacetoxy- 1,1- dimethylpiperidinium