3-(2,4-dimethoxybenzylidene)anabaseine

01/01/2020 - "Here, we tested the hypothesis that GTS-21 ameliorates sepsis-induced hepatic injury by modulating autophagy in mice. "
01/01/2020 - "GTS-21 ameliorates polymicrobial sepsis-induced hepatic injury by modulating autophagy through α7nAchRs in mice."
01/01/2022 - "GTS-21 (GTS-21 dihydrochloride), an α7nAchR agonist, was prophylactically administered in sepsis-induced ALI mouse model and LPS-primed bone marrow-derived dendritic cells. "
06/01/2018 - "GTS-21 can alleviate the LPS-induced damage in the heart via a7nAChR, and pretreatment with α-bungarotoxin obviously blocked the protective effect of GTS-21 on sepsis in mice."
06/01/2018 - "GTS-21 Protected Against LPS-Induced Sepsis Myocardial Injury in Mice Through α7nAChR."

05/01/2006 - "Conversely, GTS-21 pretreatment strongly decreased the severity of pancreatitis. "
11/01/2022 - "Surgical splenectomy performed 7 days before ERCP-induced pancreatitis blocked the protective effects of GTS-21. "
11/01/2022 - "Intravenous injection of a crude preparation of total splenocytes prepared from mice pretreated with GTS-21 inhibited ERCP-induced pancreatitis; splenocytes from mice treated with vehicle had no effect. "

08/01/2014 - "In the present study, the effects of GTS-21 on T helper 1 (Th1) cells, which have an important role in the inflammation associated with RA, were investigated. "
09/01/2023 - "We found that GTS-21 ameliorated systemic and local synovial inflammation, thereby reducing synovial macrophage infiltration in CIA mice. "
11/01/2018 - "Hypothesis tested was that modulation of inflammation by agonist GTS-21 (10 mg/kg b.i.d. "
01/01/2017 - "Hypothesis tested is that attenuation of inflammation by α7AChR stimulation with specific α7AChR agonist, GTS-21, will reverse BI-induced body mass and MW by modulating inflammatory and proteolytic signals. "
04/01/2016 - "Data on the Chrna7 mice suggest that the beneficial effects mediated by GTS-21 on inflammation and motility might be related to activation of other receptors besides the α7nAChR."

01/01/2008 - "Subsequently, GTS-21 is proved to be a good candidate for Alzheimer's disease. "
09/01/2007 - "To find new drug candidates for treating Alzheimer's disease, we used the similarity search technique and GTS-21 as a template to search the Traditional Chinese Medicines Database. "
07/01/1999 - "1. GTS-21, a novel drug for Alzheimer's disease, is currently under clinical development. "
07/01/1999 - "Metabolism and disposition of GTS-21, a novel drug for Alzheimer's disease."
11/15/1996 - "It has been suggested that GTS-21 can improve the learning deficits and inhibit the neuro-degeneration in patients with Alzheimer's disease. "

01/01/2018 - "This study evaluated the effect of GTS-21 on microvascular permeability and leukocyte adhesion during experimental endotoxemia. "
01/01/2018 - "GTS-21 has a protective effect on microvascular barrier function during endotoxemia. "
01/01/2018 - "Microvascular permeability was significantly reduced in animals treated with GTS-21 simultaneously and 1h after induction of endotoxemia. "
01/01/2018 - "GTS-21 reduces microvascular permeability during experimental endotoxemia."
12/01/2017 - "This article contains animal experimental data associated with the research article entitled "GTS-21 reduces microvascular permeability during experimental endotoxemia" (Schmidt et al., 2017) [1] (supplementary datasets of baseline intravital microscopic measurements, baseline TNF-α levels and vital parameters of the evaluated experimental groups are provided). "