|1.||Tsuji, S: 1 article (01/2001)|
|2.||Hori, M: 1 article (01/2001)|
|3.||Kawano, S: 1 article (01/2001)|
|4.||Sun, W H: 1 article (01/2001)|
|5.||Tsujii, M: 1 article (01/2001)|
|6.||Gunawan, E S: 1 article (01/2001)|
|7.||Kawai, N: 1 article (01/2001)|
03/01/1999 - "Therefore, T-593 improves the quality of ulcer healing."
12/01/1998 - "From these results, it is concluded that T-593 induces ulcer healing with a lower recurrence and/or relapse rate of ulcers than other conventional H2-antagonists, and T-593 may thus be a useful anti-ulcer drug for clinical therapy."
12/01/1998 - "In the histological measurement, the grades of heterotopic regenerated gland and inflammatory cell infiltration of T-593 was lower than those of the control and other drugs in the ulcer area. "
08/01/1998 - "This interesting property of T-593 is expected to contribute to the clinical promotion of ulcer healing."
08/01/1998 - "This interesting property of T-593 is expected to raise the quality of ulcer healing (QOUH) and also may prevent ulcer recurrence."
|2.||Stomach Ulcer (Gastric Ulcer)
03/01/1999 - "[Histological study on healing of cryocautery-induced rat gastric ulcer treated with T-593]."
02/01/1996 - "Spontaneous healing of kissing gastric ulcers was significantly enhanced when T-593 was administered for 14 days. "
12/01/1998 - "[Influence of T-593 on the recurrence and relapse of cryocautery-induced gastric ulcer in rats: sequential observation with an endoscope and histological evaluation]."
08/01/1998 - "Chronic gastric ulcer induced by acetic acid was, however, not healed by the sole treatment of each optical isomer, while racemic T-593 showed a significant effect. "
03/01/1999 - "The effect of T-593, a novel anti-ulcer agent, on the healing of cryocautery-induced rat gastric ulcer was investigated histologically in comparison with that of famotidine. "
03/01/1998 - "Additional notable features of T-593, as determined in rats, are that its protective effect on the hemorrhagic shock-induced lesion under the prior dosing of histamine is ca. 10- and 2-fold greater than ranitidine and famotidine, respectively, and that a decrease in the gastric mucosal blood flow caused by a partial blood-withdrawal is more strongly recovered with T-593 than with famotidine. "
07/01/1997 - "Thus, the protective effect of T-593 against acute gastric mucosal injury induced by ischemia and followed by reperfusion may result, in part, from its antioxidant properties."
07/01/1997 - "An ischemic injury followed by reperfusion was produced by applying a small vascular clamp to the celiac artery for 30 min and then removing it for 60 min. T-593 significantly reduced the area of the lesion in the stomach in a dose-dependent manner, and doses of 0.3 and 3.0 mg/kg inhibited the increase of lipid peroxides in the gastric mucosa after ischemia-reperfusion. "
08/01/1998 - "It was found that the total amounts of gastric bleeding and lesions after IM-WIS with perfusion of HCl were more significantly decreased in T-593 (1 mg/kg, i.v., 0.1 mg/kg/hr, d.i.)- and secretion (15 CU/kg/hr, d.i.)-treated rats, respectively. "
08/01/1998 - "The effect of T-593, a novel antiulcer agent, was investigated with respect to gastric bleeding and lesions induced by indomethacin (3 mg/kg, s.c.) and water (23 degrees C) immersion stress (IM-WIS) with perfusion of HCl (0.13N) into the rat stomach. "
08/01/1998 - "[Effect of T-593 on gastric bleeding and lesions induced by indomethacin and water-immersion stress in rats: improving effect of T-593 on reduced gastric mucosal blood flow in rats]."
|1.||Histamine (Histamine Dihydrochloride)
|5.||Acetic Acid (Vinegar)
|8.||Guanidine (Guanidine Nitrate)
|9.||Nitric Oxide (Nitrogen Monoxide)